Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides

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dc.contributor.authorBonamigo, Thaliny
dc.contributor.authorCampos, Jaqueline Ferreira
dc.contributor.authorAlfredo, Tamaeh Monteiro
dc.contributor.authorPerrella Balestieri, Jose Benedito
dc.contributor.authorLima Cardoso, Claudia Andrea
dc.contributor.authorParedes-Gamero, Edgar Julian [UNIFESP]
dc.contributor.authorSouza, Kely de Picoli
dc.contributor.authordos Santos, Edson Lucas
dc.coverageLondon
dc.date.accessioned2020-07-31T12:46:45Z
dc.date.available2020-07-31T12:46:45Z
dc.date.issued2017
dc.description.abstractPropolis is a natural mixture of compounds produced by various bee species, including stingless bees. This compound has been shown to exhibit antioxidant, antiproliferative, and antitumor activities. The present study aimed to determine the chemical constituents as well as the antioxidant, cytotoxic, and toxic activities of ethanol extracts of propolis obtained from the stingless bees Scaptotrigona depilis and Melipona quadrifasciata anthidioides, which are found in Brazil. Phytosterols, terpenes, phenolic compounds, and tocopherol were identified in the ethanol extracts of propolis (EEPs) in different concentrations. The compounds stigmasterol, taraxasterol, vanilic acid, caffeic acid, quercetin, luteolin, and apigenin were found only in EEP-M. The EEPs were able to scavenge the free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and protected human erythrocytes against lipid peroxidation, with the latter effect being demonstrated by their antihemolytic activity and inhibition of malondialdehyde formation. The EEPs showed cytotoxic activity against erythroleukemic cells and necrosis was the main mechanism of death observed. In addition, the concentrations at which the EEPs were cytotoxic were not toxic against Caenorhabditis elegans. In this context, it is concluded that EEP-S and EEP-M show antioxidant and cytotoxic activities and are promising bioactive mixtures for the control of diseases associated with oxidative stress and tumor cell proliferation.en
dc.description.affiliationFed Univ Grande Dourados, Sch Environm & Biol Sci, Dourados, MS, Brazil
dc.description.affiliationUniv Estadual Mato Grosso do Sul, Course Chem, Dourados, MS, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biochem, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Mogi Das Cruzes, Interdisciplinary Ctr Biochem Invest, Mogi Das Cruzes, SP, Brazil
dc.description.affiliationUnifespDepartment of Biochemistry, Universidade Federal de São Paulo (UNIFESP), SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1155/2017/1038153
dc.identifier.citationOxidative Medicine And Cellular Longevity. London, v. , p. -, 2017.
dc.identifier.doi10.1155/2017/1038153
dc.identifier.fileWOS000398232700001.pdf
dc.identifier.issn1942-0900
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56337
dc.identifier.wosWOS:000398232700001
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofOxidative Medicine And Cellular Longevity
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleAntioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioidesen
dc.typeinfo:eu-repo/semantics/article
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