Natural marine sponges for bone tissue engineering: The state of art and future perspectives

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dc.contributor.authorGranito, Renata Neves [UNIFESP]
dc.contributor.authorCustódio, Márcio Reis
dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.date.accessioned2019-08-19T11:50:03Z
dc.date.available2019-08-19T11:50:03Z
dc.date.issued2017
dc.description.abstractMarine life and its rich biodiversity provide a plentiful resource of potential new products for the society. Remarkably, marine organisms still remain a largely unexploited resource for biotechnology applications. Among them, marine sponges are sessile animals from the phylum Porifera dated at least from 580 million years ago. It is known that molecules from marine sponges present a huge therapeutic potential in a wide range of applications mainly due to its antitumor, antiviral, anti-inflammatory, and antibiotic effects. In this context, this article reviews all the information available in the literature about the potential of the use of marine sponges for bone tissue engineering applications. First, one of the properties that make sponges interesting as bone substitutes is their structural characteristics. Most species have an efficient interconnected porous architecture, which allows them to process a significant amount of water and facilitates the flow of fluids, mimicking an ideal bone scaffold. Second, sponges have an organic component, the spongin, which is analogous to vertebral collagen, the most widely used natural polymer for tissue regeneration. Last, osteogenic properties of marine sponges is also highlighted by their mineral content, such as biosilica and other compounds, that are able to support cell growth and to stimulate bone formation and mineralization. This review focuses on recent studies concerning these interesting properties, as well as on some challenges to be overcome in the bone tissue engineering field. (C) 2016 Wiley Periodicals, Inc.en
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Biosci IB USP, São Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Biosci, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent1717-1727
dc.identifierhttps://onlinelibrary.wiley.com/doi/full/10.1002/jbm.b.33706
dc.identifier.citationJournal Of Biomedical Materials Research Part B-Applied Biomaterials. Hoboken, v. 105, n. 6, p. 1717-1727, 2017.
dc.identifier.doi10.1002/jbm.b.33706
dc.identifier.issn1552-4973
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/51465
dc.identifier.wosWOS:000407055400038
dc.language.isoeng
dc.publisherWiley
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMarine spongesen
dc.subjectNatural biomaterialsen
dc.subjectBone tissue engineeringen
dc.subjectBiosilicaen
dc.subjectCollagenen
dc.titleNatural marine sponges for bone tissue engineering: The state of art and future perspectivesen
dc.typeinfo:eu-repo/semantics/review
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