Report of joint hypermobility in malignant hyperthermia susceptible patients: observational study with a case-control descriptive design

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dc.citation.issue2
dc.citation.volume11
dc.contributor.authorSantos , Rita CCS
dc.contributor.authorLima, Larissa FCDMS
dc.contributor.authorAndrade, Pamela V
dc.contributor.authorSantos , Joilson M
dc.contributor.authorGalleni, Leonardo
dc.contributor.authorJunior, Antonio FR
dc.contributor.authorSouza, Lucas S
dc.contributor.authorSchmidt, Beny
dc.contributor.authorOliveria , Acary SB
dc.contributor.authorAmaral, JLG
dc.contributor.authorVainzof, M
dc.contributor.authorSivla, Helga CA
dc.contributor.authorLatteshttps://lattes.cnpq.br/0844918862241102
dc.date.accessioned2025-01-23T17:18:13Z
dc.date.available2025-01-23T17:18:13Z
dc.date.issued2025-01-30
dc.description.abstractBackground Hypermobility is the capacity to perform joint movements in amplitudes greater than normal. Hypermobility is present in nearly 100 % of congenital myopathy central core disease (CCD) patients but is sporadically described in the allelic disease malignant hyperthermia (MH). Our objective was to investigate the frequency/characteristics of hypermobility in MH susceptible patients as compared to a control group, aiming the identification of correlations between hypermobility and demographic/clinical findings in MH patients. Methods. We recruited 26 MH patients (MH history, positive in vitro contracture test (IVCT), no muscle weakness, no cores in muscle biopsy) and 23 controls (no MH/myopathy history). Patients/medical records were evaluated for obtaining demographic/clinical data. Hypermobility was assessed in all patients and controls with Bulbena score. Goniometry was performed in a subset of 11 patients and 11 controls. Results. Bulbena score indicative of hypermobility was significantly more frequent in MH than in the control group (50 % versus 13 %, relative risk 2.06 (95%CI 1.27–3.35), chi-square test, p < .01). Goniometric assessment revealed significantly greater range of motion of mostly proximal movements in MH versus control groups. In the MH group, there was no correlation of the Bulbena score with age, sex, clinical complaints of myalgia/cramps, CK levels, IVCT result, or degree of contracture after caffeine or halothane. Conclusions. It is possible that predominantly proximal hypermobility is part of a clinical spectrum associated with RYR1 gene variants, as it was present even when associated muscle weakness was not present. More studies are necessary to measure evolution and long-term impact of hypermobility in MH patients.
dc.format.extente41776
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S2405844025001562
dc.identifier.citationSANTOS, R. C. C. S. et al. Report of joint hypermobility in malignant hyperthermia susceptible patients: observational study with a case-control descriptive design. Heliyon, v. 11, n. 2, p. e41776, 20 jan. 2025.
dc.identifier.doi10.1016/j.heliyon.2025.e41776
dc.identifier.issn2405-8440
dc.identifier.urihttps://hdl.handle.net/11600/72822
dc.languageeng
dc.publisherCellPress
dc.relation.ispartofHeliyon
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCentral core disease
dc.subjectGoniometry
dc.subjectJoint instability
dc.subjectMalignant hyperthermia
dc.subjectMyopathy
dc.subject.ods3. Saúde e bem-estar
dc.titleReport of joint hypermobility in malignant hyperthermia susceptible patients: observational study with a case-control descriptive design
dc.typeinfo:eu-repo/semantics/article
unifesp.aperfeicoamentoOutra (especificar nome do curso no campo Descrição)
unifesp.campusEscola Paulista de Medicina (EPM)
unifesp.departamentoCirurgia
unifesp.especializacaoOutra (especificar nome do curso no campo Descrição)
unifesp.graduacaoMedicina
unifesp.graduateProgramNeurologia-Neurociências
unifesp.knowledgeAreaNeurologia
unifesp.researchAreaHipertermia maligna
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