Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids

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dc.contributor.authorEstadella, Debora [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorRibeiro, Eliane Beraldi [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:30:52Z
dc.date.available2016-01-24T14:30:52Z
dc.date.issued2013-01-01
dc.description.abstractThe ingestion of excessive amounts of saturated fatty acids (SFAs) and transfatty acids (TFAs) is considered to be a risk factor for cardiovascular diseases, insulin resistance, dyslipidemia, and obesity. the focus of this paper was to elucidate the influence of dietary SFA and TFA intake on the promotion of lipotoxicity to the liver and cardiovascular, endothelial, and gut microbiota systems, as well as on insulin resistance and endoplasmic reticulum stress. the saturated and transfatty acids favor a proinflammatory state leading to insulin resistance. These fatty acids can be involved in several inflammatory pathways, contributing to disease progression in chronic inflammation, autoimmunity, allergy, cancer, atherosclerosis, hypertension, and heart hypertrophy as well as other metabolic and degenerative diseases. As a consequence, lipotoxicity may occur in several target organs by direct effects, represented by inflammation pathways, and through indirect effects, including an important alteration in the gut microbiota associated with endotoxemia. Interactions between these pathways may perpetuate a feedback process that exacerbates an inflammatory state. the importance of lifestyle modification, including an improved diet, is recommended as a strategy for treatment of these diseases.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, EPM, Disciplina Fisiol Nutr, Programa Posgrad Nutr, BR-04023060 São Paulo, Brazil
dc.description.affiliationUNIFESP, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, EPM, Disciplina Fisiol Nutr, Programa Posgrad Nutr, BR-04023060 São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2010/20079-2
dc.description.sponsorshipIDCAPES: 007419/2011-21
dc.description.sponsorshipIDCNPq: 161433/2011-1
dc.format.extent13
dc.identifierhttps://dx.doi.org/10.1155/2013/137579
dc.identifier.citationMediators of Inflammation. New York: Hindawi Publishing Corporation, 13 p., 2013.
dc.identifier.doi10.1155/2013/137579
dc.identifier.fileWOS000314583300001.pdf
dc.identifier.issn0962-9351
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/35679
dc.identifier.wosWOS:000314583300001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofMediators of Inflammation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleLipotoxicity: Effects of Dietary Saturated and Transfatty Acidsen
dc.typeinfo:eu-repo/semantics/article
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