Effects of valproic acid on an animal model of tardive dyskinesia

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dc.contributor.authorPeixoto, M. F.
dc.contributor.authorAbilio, V. C.
dc.contributor.authorSilva, R. H.
dc.contributor.authorFrussa, R.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:54Z
dc.date.available2016-01-24T12:33:54Z
dc.date.issued2003-06-16
dc.description.abstractGABAergic hypofunction in the basal ganglia is stated as an important mechanism underlying the pathophysiology of tardive dyskinesia. the present study investigates the effects of the GABA-mimetic drug valproic acid (VA) on the manifestation of reserpine-induced orofacial movements, an animal model of tardive dyskinesia. Male Wistar rats received two injections of control solution or of 1 mg/kg reserpine separated by 48 h. Twenty-four hours later, animals were acutely treated with 50, 100, or 200 mg/kg VA or control solution and were observed for quantification of orofacial movements and of open-field general activity. the highest dose of VA inhibited the manifestation of reserpine-induced orofacial movements but none of the VA doses modified reserpine-induced decrease in open-field general activity. These results support the potential of VA as an effective pharmacological tool in the treatment of tardive dyskinesia. (C) 2003 Elsevier Science B.V. All rights reserved.en
dc.description.affiliationUNIFESP, Escola Paulista Med, Dept Pharmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Escola Paulista Med, Dept Pharmacol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent229-233
dc.identifierhttp://dx.doi.org/10.1016/S0166-4328(03)00025-1
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 142, n. 1-2, p. 229-233, 2003.
dc.identifier.doi10.1016/S0166-4328(03)00025-1
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27292
dc.identifier.wosWOS:000183679600024
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectGABAen
dc.subjecttardive dyskinesiaen
dc.subjectvalproic aciden
dc.subjectreserpineen
dc.subjectratsen
dc.subjectbehavioren
dc.titleEffects of valproic acid on an animal model of tardive dyskinesiaen
dc.typeinfo:eu-repo/semantics/article
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