Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis

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dc.contributor.authorde Camargo, Leonardo Valente
dc.contributor.authorde Carvalho, Mary Souza
dc.contributor.authorShinjo, Samuel Katsuyuki
dc.contributor.authorBulle de Oliveira, Acary Souza [UNIFESP]
dc.contributor.authorZanoteli, Edmar
dc.coverageLondon
dc.date.accessioned2020-07-02T18:52:07Z
dc.date.available2020-07-02T18:52:07Z
dc.date.issued2018
dc.description.abstractSporadic inclusion body myositis (sIBM) is considered the most common acquired myopathy aged over 50 years. The disease is characterized by a particular process of muscle degeneration characterized by abnormal deposit of protein aggregates in association with inflammation. The aim of this study was to present clinical and muscle histopathological findings, including immunostaining for LC3B, p62, alpha-synuclein, and TDP-43, in 18 patients with sIBM. The disease predominated in males (61%) and European descendants, with onset of clinical manifestations around 59 years old. The most common symptoms were muscle weakness, falls, dysphagia, and weight loss. Hypertension was the main comorbidity. Most of the cases presented with paresis predominantly proximal in lower limbs and distal in upper limbs. Immunosuppressive treatment showed to be not effective. Muscle histological findings included dystrophic changes, endomysial inflammation, increased lysosomal activity, and presence of rimmed vacuoles and of beta-amyloid accumulation, in addition to high frequency of mitochondrial changes. There was increased expression of LC3B, p62, alpha-synuclein, and TDP-43 in muscle biopsies. The sIBM has characteristic clinical and histological findings, and the use of degeneration and autophagic markers can be useful for the diagnosis.en
dc.description.affiliationUniv Sao Paulo, Fac Med, Disciplina Reumatol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Disciplina Neurol, Setor Doencas Neuromusculares, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Disciplina Neurol, Setor Doencas Neuromusculares, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1155/2018/5069042
dc.identifier.citationBiomed Research International. London, v. , p. -, 2018.
dc.identifier.doi10.1155/2018/5069042
dc.identifier.fileWOS000423796100001.pdf
dc.identifier.issn2314-6133
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53887
dc.identifier.wosWOS:000423796100001
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofBiomed Research International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleClinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositisen
dc.typeinfo:eu-repo/semantics/article
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