Risk factors for recurrent wheezing - international study of wheezing in infants (eisl) phase 3

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dc.contributor.authorAranda, Carolina Sanchez [UNIFESP]
dc.contributor.authorWandalsen, Gustavo Falbo [UNIFESP]
dc.contributor.authorFonzar, Ligia Furtado [UNIFESP]
dc.contributor.authorDela Bianca, Ana Caroline Cavalcanti
dc.contributor.authorMallol, Javier
dc.contributor.authorSolé, Dirceu [UNIFESP]
dc.date.accessioned2019-01-21T10:30:12Z
dc.date.available2019-01-21T10:30:12Z
dc.date.issued2016
dc.description.abstractBackground: We aimed to identify factors associated with recurrent wheezing (RW) in infants in the first year of life living in the Southern region of Sao Paulo city and participating in the "Estudio Internacional de Sibilancias en Lactantes (EISL)" - phase 3 (P3). Methods: 1335 parents of infants who were attended in primary care health units in the Southern region of Sao Paulo city from 2009 to 2010 answered the EISL-P3 written questionnaire. The wheezing group was stratified in accordance to the frequency of wheezing episodes as occasional wheezing (OW, less than three episodes), or RW (three or more episodes). Wheezing-associated factors were evaluated using multivariate analysis and were expressed as odds ratio (OR) and 95% confidence interval (95%CI). Results: The most relevant factors related to OW were pneumonia (OR = 3.10, 95%CI=1.68-5.73), hospitalisation due to pneumonia (OR = 2.88, 95%CI = 1.26-6.56) and recurrent upper respiratory infection (URI, OR = 1.87, 95%CI = 1.25-2.81). Regarding RW, recurrent URI (OR = 5.34, 95%CI = 3.83-7.45), pneumonia (OR= 4.06, 95%CI = 2.87-5.74) and asthmatic siblings (OR= 3.02, 95%CI = 1.67-5.45) were the most significantly associated factors. Conclusions: In the present study, we found that recurrent URI, positive history of pneumonia and familiar history of asthma were the most relevant factors associated with RW. The precocious knowledge of these factors can enable the identification of the probable asthmatic infants and can improve both prevention strategies and treatment of these patients. (C) 2014 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.en
dc.description.affiliationFederal University of São Paulo-Escola Paulista de Medicina (UNIFESP-EPM), São Paulo, Brazil
dc.description.affiliationFederal University of Pernambuco, Recife, Brazil
dc.description.affiliationHospital CRS El Pino, University of Santiago, Santiago, Chile
dc.description.affiliationUnifespFederal University of São Paulo-Escola Paulista de Medicina (UNIFESP-EPM), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent3-8
dc.identifierhttp://dx.doi.org/10.1016/j.aller.2015.05.011
dc.identifier.citationAllergologia Et Immunopathologia. Barcelona, v. 44, n. 1, p. 3-8, 2016.
dc.identifier.doi10.1016/j.aller.2015.05.011
dc.identifier.issn0301-0546
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49636
dc.identifier.wosWOS:000369047300002
dc.language.isoeng
dc.publisherElsevier doyma sl
dc.relation.ispartofAllergologia Et Immunopathologia
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAsthmaen
dc.subjectInfantsen
dc.subjectRespiratory Soundsen
dc.subjectRespiratory Tract Infectionsen
dc.subjectRisk Factors1st Yearen
dc.subjectChildhood Asthmaen
dc.subjectLifeen
dc.subjectPrevalenceen
dc.subjectInfectionsen
dc.subjectExposureen
dc.subjectQuestionnaireen
dc.subjectAcetaminophenen
dc.subjectValidationen
dc.subjectDisordersen
dc.titleRisk factors for recurrent wheezing - international study of wheezing in infants (eisl) phase 3en
dc.typeinfo:eu-repo/semantics/article
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