Effects of Sleep Deprivation on Memory in Mice: Role of State-Dependent Learning

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dc.contributor.authorPatti, Camilla L. [UNIFESP]
dc.contributor.authorZanin, Karina A. [UNIFESP]
dc.contributor.authorSanday, Leandro [UNIFESP]
dc.contributor.authorKameda, Sonia R. [UNIFESP]
dc.contributor.authorFernandes-Santos, Luciano [UNIFESP]
dc.contributor.authorFernandes, Helaine A. [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T12:11:58Z
dc.date.available2018-06-18T12:11:58Z
dc.date.issued2010-12-01
dc.description.abstractStudy Objectives: A considerable amount of experimental evidence suggests that sleep plays a critical role in learning/memory processes. In addition to paradoxical sleep, slow wave sleep is also reported to be involved in the consolidation process of memories. Additionally, sleep deprivation can induce other behavioral modifications, such as emotionality and alternations in locomotor activity in rodents. These sleep deprivation-induced alterations in the behavioral state of animals could produce state-dependent learning and contribute, at least in part, to the amnestic effects of sleep deprivation. The aim of the present study was to examine the participation of state-dependent learning during memory impairment induced by either paradoxical sleep deprivation (PSD) or total sleep deprivation (TSD) in mice submitted to the plus-maze discriminative avoidance or to the passive avoidance task.Design: Paradoxical sleep deprivation (by the multiple platform method) and total sleep deprivation (by the gentle handling method) were applied to animals before training and/or testing.Conclusions: Whereas pre-training or pre-test PSD impaired retrieval in both memory models, pre-training plus pre-test PSD counteracted this impairment. For TSD, pre-training, pre-test, and pre-training plus pre-test TSD impaired retrieval in both models. Our data demonstrate that PSD(but not ISO-) memory deficits are critically related to state-dependent learning.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipAssociacao Fundo de Pesquisa em Psicobiologia (AFIP)
dc.format.extent1669-1679
dc.identifierhttps://doi.org/10.1093/sleep.33.12.1669
dc.identifier.citationSleep. Westchester: Amer Acad Sleep Medicine, v. 33, n. 12, p. 1669-1679, 2010.
dc.identifier.issn0161-8105
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45607
dc.identifier.wosWOS:000284719900012
dc.language.isoeng
dc.publisherAmer Acad Sleep Medicine
dc.relation.ispartofSleep
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSleepen
dc.subjectmemoryen
dc.subjectstate-dependencyen
dc.titleEffects of Sleep Deprivation on Memory in Mice: Role of State-Dependent Learningen
dc.typeinfo:eu-repo/semantics/article
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