Comorbidity variation in patients with obsessive-compulsive disorder according to symptom dimensions: results from a large multicentre clinical sample

Página do item simplificado
dc.contributor.authorTorres, Albina Rodrigues
dc.contributor.authorFontenelle, Leonardo Franklin da Costa
dc.contributor.authorShavitt, Roseli Gedanke
dc.contributor.authorFerrão, Ygor Arzeno
dc.contributor.authorRosario, Maria Conceicao do [UNIFESP]
dc.contributor.authorStorch, Eric A.
dc.contributor.authorMiguel, Euripedes Constantino
dc.date.accessioned2019-01-21T10:29:21Z
dc.date.available2019-01-21T10:29:21Z
dc.date.issued2016
dc.description.abstractBackground: Obsessive-compulsive disorder (OCD) has a heterogeneous and complex phenomenological picture, characterized by different symptom dimensions and comorbid psychiatric disorders, which frequently co-occur or are replaced by others over the illness course. To date, very few studies have investigated the associations between specific OCD symptom dimensions and comorbid disorders. Methods: Cross-sectional, multicenter clinical study with 1001 well-characterized OCD patients recruited within the Brazilian Research Consortium on Obsessive-Compulsive and Related Disorders. The primary instruments were the Dimensional Yale-Brown Obsessive Compulsive Scale (DY-BOCS) and the Structured Clinical Interview for DSM-IV Axis I Disorders. Bivariate analyses between symptom dimensions and comorbidities were followed by logistic regression. Results: The most common comorbidities among participants (56.8% females) were major depression (56.4%), social phobia (34.6%), generalized anxiety disorder (34.3%), and specific phobia (31.4%). The aggressive dimension was independently associated with posttraumatic stress disorder (PTSD), separation anxiety disorder, any impulse-control disorder and skin pickingen
dc.description.abstractthe sexual-religious dimension was associated with mood disorders, panic disorder/agoraphobia, social phobia, separation anxiety disorder, non-paraphilic sexual disorder, any somatoform disorder, body dysmorphic disorder and tic disordersen
dc.description.abstractthe contamination-cleaning dimension was related to hypochondriasisen
dc.description.abstractand the hoarding dimension was associated with depressive disorders, specific phobia, PTSD, impulse control disorders (compulsive buying, skin picking, internet use), ADHD and tic disorders. The symmetry-ordering dimension was not independently associated with any comorbidity. Limitations: Cross-sectional designen
dc.description.abstractparticipants from only tertiary mental health servicesen
dc.description.abstractpersonality disorders not investigated. Conclusions: Different OCD dimensions presented some specific associations with comorbid disorders, which may influence treatment seeking behaviors and response, and be suggestive of different underlying pathogenic mechanisms. (C) 2015 Elsevier B.V. All rights reserved.en
dc.description.affiliationDepartment of Neurology, Psychology and Psychiatry, Botucatu Medical School, Univ Estadual Paulista, Brazil
dc.description.affiliationAnxiety and Depression Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro
dc.description.affiliationD'Or Institute for Research and Education, Brazil
dc.description.affiliationDepartment of Psychiatry, University of São Paulo Medical School, Brazil
dc.description.affiliationDepartment of Psychiatry, Health Sciences Federal University of Porto Alegre, Brazil
dc.description.affiliationChild and Adolescent Psychiatry Unit (UPIA) at the Department of Psychiatry, Federal University of São Paulo, Brazil
dc.description.affiliationDepartment of Pediatrics and Department of Health Policy and Management, University of South Florida, Rogers Behavioral Health – Tampa Bay
dc.description.affiliationAll Children's Hospital – Johns Hopkins Medicine, Tampa, FL 33620 USA
dc.description.affiliationUnifespChild and Adolescent Psychiatry Unit (UPIA) at the Department of Psychiatry, Federal University of São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent508-516
dc.identifierhttps://doi.org/10.1016/j.jad.2015.10.051
dc.identifier.citationJournal Of Affective Disorders. Amsterdam, v. 190, p. 508-516, 2016.
dc.identifier.doi10.1016/j.jad.2015.10.051
dc.identifier.issn0165-0327
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49185
dc.identifier.wosWOS:000366463000073
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal Of Affective Disorders
dc.rightsAcesso restrito
dc.subjectObsessive-Compulsive Disorderen
dc.subjectSymptom Dimensionsen
dc.subjectComorbidityen
dc.subjectComorbid DisordersOcd Collaborative Geneticsen
dc.subjectTemporal Stabilityen
dc.subjectHoarding Symptomsen
dc.subjectSexual Obsessionsen
dc.subjectSibling Pairsen
dc.subjectHelp-Seekingen
dc.subjectFollow-Upen
dc.subjectPrevalenceen
dc.subjectBehavioren
dc.subjectImpacten
dc.titleComorbidity variation in patients with obsessive-compulsive disorder according to symptom dimensions: results from a large multicentre clinical sampleen
dc.typeArtigo
Arquivos
Coleções
EPM - Artigos