Dispersion of chitosan in liquid crystalline lamellar phase: Production of biofriendly hydrogel of nano cubic topology

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dc.citation.volume157
dc.contributor.authorMathews, Patrick D.
dc.contributor.authorMertins, Omar [UNIFESP]
dc.coverageOxford
dc.date.accessioned2020-07-17T14:02:58Z
dc.date.available2020-07-17T14:02:58Z
dc.date.issued2017
dc.description.abstractBicontinuous cubic phases were produced with introduction of chitosan in phospholipid/water hydro gel, providing composites of defined molecular organization. The ratio of lipid/water was constant and swelling of lipids bilayer is delimited by incorporation of polymer molecules into the structure. By means of synchrotron small angle X-ray scattering we identified topologies of coexisting cubic phases. The expected liquid crystalline L-alpha, lamellar phase was suppressed by 0.2 wt% chitosan leading to formation of diamond Pn3m and gyroid la3d cubic topology, with close lattice distances. An increment to 0.4 wt% chitosan caused large increase in Pn3m lattice distance. However a higher 0.6 wt% evolved this phase to a newly acquired primitive Im3m topology. The structuring process of the three-dimensional complex network is principally governed by demands of chitosan physical requirements over lipids bilayers interfacial curvature. The composite hydrogel of specific topologies presents reduced time release of gallic acid and may find application as new material for time-sustained delivery of bioactive compounds. (C) 2016 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Anim Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Paulista Sch Med, Dept Biophys, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Paulista Sch Med, Dept Biophys, BR-04023062 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipBrazilian Synchrotron Light Laboratory (LNLS)
dc.description.sponsorshipIDFAPESP: 2015/23948-5
dc.format.extent850-857
dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2016.10.071
dc.identifier.citationCarbohydrate Polymers. Oxford, v. 157, p. 850-857, 2017.
dc.identifier.doi10.1016/j.carbpol.2016.10.071
dc.identifier.issn0144-8617
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55109
dc.identifier.wosWOS:000391896800096
dc.language.isoeng
dc.publisherElsevier Sci Ltd
dc.relation.ispartofCarbohydrate Polymers
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectPhospholipid-chitosan gelen
dc.subjectSAXSen
dc.subjectCubic phaseen
dc.subjectStructureen
dc.subjectBiomembraneen
dc.titleDispersion of chitosan in liquid crystalline lamellar phase: Production of biofriendly hydrogel of nano cubic topologyen
dc.typeinfo:eu-repo/semantics/article
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