Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus

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dc.contributor.authorLeite, Cleo A. C. [UNIFESP]
dc.contributor.authorTaylor, Edwin W.
dc.contributor.authorWang, Tobias
dc.contributor.authorAbe, Augusto S.
dc.contributor.authorAndrade, Denis O. V. de
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Birmingham
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionAarhus Univ
dc.date.accessioned2016-01-24T14:31:38Z
dc.date.available2016-01-24T14:31:38Z
dc.date.issued2013-05-01
dc.description.abstractThe morphologically undivided ventricle of the heart in non-crocodilian reptiles permits the mixing of oxygen-rich blood returning from the lungs and oxygen-poor blood from the systemic circulation. A possible functional significance for this intra-cardiac shunt has been debated for almost a century. Unilateral left vagotomy rendered the single effective pulmonary artery of the South American rattlesnake, Crotalus durissus, unable to adjust the magnitude of blood flow to the lung. the higher constant perfusion of the lung circulation and the incapability of adjusting the right-left shunt in left-denervated snakes persisted over time, providing a unique model for investigation of the long-term consequences of cardiac shunting in a squamate. Oxygen uptake recorded at rest and during spontaneous and forced activity was not affected by removing control of the cardiac shunt. Furthermore, metabolic rate and energetic balance during the post-prandial metabolic increment, plus the food conversion efficiency and growth rate, were all similarly unaffected. These results show that control of cardiac shunting is not associated with a clear functional advantage in adjusting metabolic rate, effectiveness of digestion or growth rates.en
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Biol, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUniv Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
dc.description.affiliationState Univ São Paulo UNESP, Dept Zool, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationAarhus Univ, Dept Biosci, DK-8000 Aarhus C, Denmark
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Biol, BR-09972270 Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipDanish Research Council
dc.format.extent1881-1889
dc.identifierhttp://dx.doi.org/10.1242/jeb.083840
dc.identifier.citationJournal of Experimental Biology. Cambridge: Company of Biologists Ltd, v. 216, n. 10, p. 1881-1889, 2013.
dc.identifier.doi10.1242/jeb.083840
dc.identifier.fileWOS000318483600021.pdf
dc.identifier.issn0022-0949
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36247
dc.identifier.wosWOS:000318483600021
dc.language.isoeng
dc.publisherCompany of Biologists Ltd
dc.relation.ispartofJournal of Experimental Biology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcardiac shunten
dc.subjectvagotomyen
dc.subjectrattlesnakeen
dc.subjectCrotalusen
dc.subjectoxygen uptakeen
dc.subjecthearten
dc.titleAblation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissusen
dc.typeinfo:eu-repo/semantics/article
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