Immunohistochemical analysis of adhesion molecule expression on muscle biopsy specimens from patients with juvenile dermatomyositis

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dc.contributor.authorSallum, Adriana ME
dc.contributor.authorMarie, Suely KN
dc.contributor.authorWakamatsu, Alda
dc.contributor.authorSachetti, Silvana
dc.contributor.authorVianna, Maria AG
dc.contributor.authorSilva, Clóvis AA
dc.contributor.authorKiss, Maria HB
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionAdolfo Lutz Inst
dc.date.accessioned2018-06-18T10:46:10Z
dc.date.available2018-06-18T10:46:10Z
dc.date.issued2004-04-01
dc.description.abstractObjective. To assess expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on muscle biopsy specimens from patients with untreated juvenile dermatomyositis (JDM).Methods. Histochemical and immunohistochemical tests for ICAM-1 and VCAM-1 were performed on serial frozen sections from 27 JDM muscle biopsy specimens. ICAM-1 and VCAM-1 expression was analyzed on capillaries, perimysial and endomysial large vessels, and muscle fibers. Expression was assessed and graded semiquantitatively.Results. Increased ICAM-1 expression was observed on capillaries and perimysial large vessels on semiquantitative analysis, and was statistically more evident than on endomysial large vessels. In all cases, only a few muscle vessels showed expression of VCAM-1. Expression of ICAM-1 and VCAM-1 was observed on few muscle fibers.Conclusion. The observation of ICAM-1 expression on muscle vessels, mainly on capillaries of patients with untreated JDM compared to controls, and. VCAM-1 expression to a lesser extent, mostly on muscle vessels surrounded by inflammatory infiltrate, supports the participation of these adhesion molecules in the pathologic mechanism of vascular injury in JDM.en
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Neurol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Rheumatol, Sao Paulo, Brazil
dc.description.affiliationSanat Casa Misericordia Sao Paulo Med Sch, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationAdolfo Lutz Inst, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent801-807
dc.identifierhttp://www.jrheum.org/content/31/4/801
dc.identifier.citationJournal Of Rheumatology. Toronto: J Rheumatol Publ Co, v. 31, n. 4, p. 801-807, 2004.
dc.identifier.issn0315-162X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44674
dc.identifier.wosWOS:000220673000031
dc.language.isoeng
dc.publisherJ Rheumatol Publ Co
dc.relation.ispartofJournal Of Rheumatology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectjuvenile dermatomyositisen
dc.subjectadhesion moleculesen
dc.subjectmuscle biopsyen
dc.subjectintercellular adhesion molecule-1en
dc.subjectvascular cell adhesion molecule-1en
dc.titleImmunohistochemical analysis of adhesion molecule expression on muscle biopsy specimens from patients with juvenile dermatomyositisen
dc.typeinfo:eu-repo/semantics/article
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