Effect of glucan on murine lupus evolution and on host resistance to Klebsiella pneumoniae

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dc.contributor.authorHarima, Helena Aiko [UNIFESP]
dc.contributor.authorMendes, Nelson Figueiredo [UNIFESP]
dc.contributor.authorMamizuka, Elsa Masae [UNIFESP]
dc.contributor.authorMariano, Mario [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-15T17:53:14Z
dc.date.available2018-06-15T17:53:14Z
dc.date.issued1997-01-01
dc.description.abstractGlucan is a polysaccharide from the yeast Saccharomyces cerevisiae that stimulates the mononuclear phagocytic system (MPS). NZB/NZW F1 mice were divided into two groups: one group received a subcutaneous injection of 0.5 mg glucan/animal for 1 week, and the other received the same dose for 3 months. No changes were observed in those animals submitted to short-term glucan treatment, whereas animals with active lupus and submitted to long-term glucan administration presented early death, with significant differences in accumulated mortality rates over 33-37 weeks, when compared to controls. No deaths were observed in lupus mice treated with glucan 24 hours before the induction of septic shock by Klebsiella pneumoniae, in contrast to mortality of 95.3% in the control group during the follow-up period of 12 days. We conclude that although glucan is able to exacerbate lupus activity, it enhances resistance to infection in lupus mice. (C) 1997 Wiley-Liss, Inc.en
dc.description.affiliationUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DISCIPLINA IMUNOL,DEPT MICROBIOL IMUNOL & PARASITOL,SAO PAULO,BRAZIL
dc.description.affiliationUNIV SAO PAULO,FAC FARM,DEPT ANAL CLIN & TOXICOL,SAO PAULO,BRAZIL
dc.description.affiliationUNIV SAO PAULO,INST CIENCIAS BIOMED,DEPT IMUNOL,BR-05508 SAO PAULO,BRAZIL
dc.description.affiliationUnifespUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DISCIPLINA IMUNOL,DEPT MICROBIOL IMUNOL & PARASITOL,SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent175-178
dc.identifierhttps://doi.org/10.1002/(SICI)1098-2825(1997)11:3<175
dc.identifier.citationJournal Of Clinical Laboratory Analysis. New York: Wiley-liss, v. 11, n. 3, p. 175-178, 1997.
dc.identifier.doi10.1002/(SICI)1098-2825(1997)11:3<175
dc.identifier.issn0887-8013
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44268
dc.identifier.wosWOS:A1997WW31600010
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Clinical Laboratory Analysis
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectglucanen
dc.subjectlupusen
dc.subjectimmunomodulationen
dc.subjectresistanceen
dc.subjectKlebsiellaen
dc.titleEffect of glucan on murine lupus evolution and on host resistance to Klebsiella pneumoniaeen
dc.typeinfo:eu-repo/semantics/article
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