m1 Acetylcholine Receptor Expression is Decreased in Hippocampal CA1 region of Aged Epileptic Animals

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dc.contributor.authorCavarsan, Clarissa Fantin [UNIFESP]
dc.contributor.authorAvanzi, Renata Della Torre [UNIFESP]
dc.contributor.authorQueiroz, Claudio Marcos [UNIFESP]
dc.contributor.authorXavier, Gilberto Fernando [UNIFESP]
dc.contributor.authorMello, Luiz Eugenio Araujo de Moraes [UNIFESP]
dc.contributor.authorCovolan, Luciene [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-15T12:47:35Z
dc.date.available2018-06-15T12:47:35Z
dc.date.issued2011-08-01
dc.description.abstractIn the present study, we investigated the possible additive effects of epilepsy and aging on the expression of m1 muscarinic acetylcholine receptors (AChR) in the rat hippocampus. Young (3 months) and Aged (20 months) male, Wistar rats were treated with pilocarpine to induce status epilepticus (SE). Immunohistochemical procedure for m1 AChR detection was performed 2 months after pilocarpine-induced SE. In the CA1 pyramidal region m1 AChR staining was significantly decreased in aged epileptic animals when compared to young epileptic and aged control rats, indicating that the aging effect is worsened by the epileptic condition. However, the Nissl-stained cell analysis indicated that the number of pyramidal CA1 neurons was similarly reduced in both epileptic groups, young and aged animals. Therefore, our data suggest that the progressive reduction of m1 AChR expression in CA1 pyramidal cells of aged epileptic rats might bear relevance to the associated progressive cognitive impairment.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Inst Brain, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUniv Sao Paulo, Biosci Inst, Dept Physiol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Physiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2006/60256-5
dc.format.extent301-307
dc.identifierhttp://dx.doi.org/10.14336/AD.2011.0816
dc.identifier.citationAging And Disease. Fort Worth: Int Soc Aging & Disease, v. 2, n. 4, p. 301-307, 2011.
dc.identifier.doi10.14336/AD.2011.0816
dc.identifier.fileWOS000208950400005.pdf
dc.identifier.issn2152-5250
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42131
dc.identifier.wosWOS:000208950400005
dc.language.isoeng
dc.publisherInt Soc Aging & Disease
dc.relation.ispartofAging And Disease
dc.rightsAcesso aberto
dc.subjectEpilepsyen
dc.subjectm1 ACh receptoren
dc.subjectAgingen
dc.subjectHippocampusen
dc.subjectPilocarpineen
dc.titlem1 Acetylcholine Receptor Expression is Decreased in Hippocampal CA1 region of Aged Epileptic Animalsen
dc.typeArtigo
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