Trans fatty acids in maternal diet may impair lipid biosynthesis in mammary gland of lactating rats

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dc.contributor.authorAssumpção, Renata Pereira
dc.contributor.authorSantos, Flávia Duarte
dc.contributor.authorSetta, Cecília Leal
dc.contributor.authorBarreto, Giselle Freire
dc.contributor.authorMatta, Isabela Escórcio Augusto da
dc.contributor.authorEstadella, Debora [UNIFESP]
dc.contributor.authorAzeredo, Vilma Blondet de
dc.contributor.authorCarmo, Maria das Graças Tavares do
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.date.accessioned2016-01-24T12:33:31Z
dc.date.available2016-01-24T12:33:31Z
dc.date.issued2002-09-01
dc.description.abstractAlthough trans fatty acids are known to influence essential fatty acid (EFA) metabolism and serum levels of lipids and lipoproteins, little is known about their effects on the metabolism of mammary glands (MGs) during lactation. in this study, 5 groups of lactating Wistar rats were fed semisynthetic diets containing 7% soy oil (control); 7% partially hydrogenated vegetable oil (7% PHVO); 13% PHVO +7% soy oil (13% PHVO); 5% PHVO +2% soy oil (5% PHVO), and 3.5% PHVO +3.5% soy oil (3.5% PHVO). Dams were killed on the 12th day of lactation. Weight, lipid content (LC), in vivo lipogenesis rate (LR) and activity of the lipogenic (ATP-citrate lyase and malic) enzymes were evaluated in the MGs. Maternal food intake, weight gain, and total MG weight were not found to be significantly different between the groups. the groups with 13, 7 and 5% PHVO presented a lower (p < 0.05) LR in MGs when compared to controls, whereas MG LC was higher in the 7 and 13% groups than in controls. the observed decrease in MG lipogenesis was accompanied by a diminution (p < 0.05) in the activities of ATP-citrate lyase and malic enzymes. These data indicate a potential impairment of lipid metabolism in the MG by trans isomers in lactating rats. Copyright (C) 2002 S. Karger AG, Basel.en
dc.description.affiliationFed Univ Rio de Janeiro, Inst Nutr, Ctr Ciencias Saude, BR-21944159 Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol Endocrina & Neurofisiol, São Paulo, Brazil
dc.description.affiliationUniv Fed Fluminense, Fac Nutr, Rio de Janeiro, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol Endocrina & Neurofisiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent169-175
dc.identifierhttps://dx.doi.org/10.1159/000065403
dc.identifier.citationAnnals of Nutrition and Metabolism. Basel: Karger, v. 46, n. 5, p. 169-175, 2002.
dc.identifier.doi10.1159/000065403
dc.identifier.issn0250-6807
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/26971
dc.identifier.wosWOS:000178862700002
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofAnnals of Nutrition and Metabolism
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.karger.com/Services/RightsPermissions
dc.subjectLactationen
dc.subjectTrans fatty acidsen
dc.subjectRat pup's growthen
dc.subjectLiveren
dc.subjectMammary glanden
dc.subjectLipogenesisen
dc.subjectMalic enzymeen
dc.subjectATP-citrate lyase enzymeen
dc.titleTrans fatty acids in maternal diet may impair lipid biosynthesis in mammary gland of lactating ratsen
dc.typeinfo:eu-repo/semantics/article
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