Chitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoin

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dc.contributor.authorRidolfi, Daniela M.
dc.contributor.authorMarcato, Priscyla D.
dc.contributor.authorJusto, Giselle Z. [UNIFESP]
dc.contributor.authorCordi, Livia
dc.contributor.authorMachado, Daisy
dc.contributor.authorDuran, Nelson
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2016-01-24T14:27:11Z
dc.date.available2016-01-24T14:27:11Z
dc.date.issued2012-05-01
dc.description.abstractTretinoin (TRE) or all-trans retinoic acid is employed in the topical treatment of various skin diseases including acne and psoriasis. However, its use is strongly limited by side effects and high chemical instability. TRE encapsulation in nanostructured systems reduces these problems. Chitosan is a biopolymer that exhibits a number of interesting properties such as bioadhesion and antibacterial activity. the aim of this work was to prepare and characterize solid lipid nanoparticles (SLN) containing TRE, with and without addition of chitosan, to assess their in vitro cytotoxicity in keratinocytes and to evaluate their antibacterial activity against bacteria related to acne. SLN without (SLN-TRE) and with (SLN-chitosan-TRE) chitosan were prepared by hot high pressure homogenization. the hydrodynamic mean diameter and zeta potential were 162.7 +/- 1.4 nm and -31.9 +/- 2.0 mV for SLN-TRE, and 284.8 +/- 15.0 nm and 55.9 +/- 3.1 mV for SLN-chitosan-TRE. the SLN-chitosan-TRE exhibited high encapsulation efficiency, high physical stability in the tested period (one year), were not cytotoxic to keratinocytes and showed high antibacterial activity against P. acnes and S. aureus. Therefore chitosan-SLN can be good candidates to encapsulate TRE and to increase its therapeutic efficacy in the topical treatment of acne. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, Inst Quim, Biol Chem Lab, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Biochem, Inst Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Biol Sci Dept Campus Diadema, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Biochem Dept Campus São Paulo, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Genet Evolut & Bioagents Dept, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Nat & Human Sci, Santo Andre, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Biol Sci Dept Campus Diadema, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Biochem Dept Campus São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent36-40
dc.identifierhttp://dx.doi.org/10.1016/j.colsurfb.2011.11.051
dc.identifier.citationColloids and Surfaces B-biointerfaces. Amsterdam: Elsevier B.V., v. 93, p. 36-40, 2012.
dc.identifier.doi10.1016/j.colsurfb.2011.11.051
dc.identifier.issn0927-7765
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34853
dc.identifier.wosWOS:000302431900006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofColloids and Surfaces B-biointerfaces
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAll-trans retinoic aciden
dc.subjectAntibacterial activityen
dc.subjectChitosanen
dc.subjectCytotoxicityen
dc.subjectSolid lipid nanoparticlesen
dc.subjectTretinoinen
dc.titleChitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoinen
dc.typeinfo:eu-repo/semantics/article
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