Functional resonance magnetic imaging (fMRI) in adolescents with idiopathic musculoskeletal pain: a paradigm of experimental pain

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dc.citation.volume15
dc.contributor.authorMolina, Juliana [UNIFESP]
dc.contributor.authorAmaro, Edson, Jr.
dc.contributor.authorSanches da Rocha, Liana Guerra
dc.contributor.authorJorge, Liliana
dc.contributor.authorSantos, Flavia Heloisa
dc.contributor.authorLen, Claudio A. [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-09-01T13:21:17Z
dc.date.available2020-09-01T13:21:17Z
dc.date.issued2017
dc.description.abstractBackground: Studies on functional magnetic resonance imaging (fMRI) have shown that adults with musculoskeletal pain syndromes tolerate smaller amount of pressure (pain) as well as differences in brain activation patterns in areas related to pain. The objective of this study was to evaluate, through fMRI, the brain activation in adolescents with idiopathic musculoskeletal pain (IMP) while performing an experimental paradigm of pain. Methods: The study included 10 consecutive adolescents with idiopathic musculoskeletal pain (average age 16.3 +/- 1.0) and 10 healthy adolescents age-matched. fMRI exams were performed in a 3 T scanner (Magnetom Trio, Siemens) using an event-related design paradigm. Pressure stimuli were performed in the nondominant hand thumb, divided into two stages, fixed pain and variable pain. The two local Research Ethics Committees (Ethics Committee from Universidade Federal de Sao Paulo- Brazil, process number 0688/11, on July 1st, 2011 and Ethics Committee from Hospital Israelita Albert Einsten - Brazil, process number 1673, on October 19th, 2011) approved the study. Results: The idiopathic musculoskeletal pain (IMP) group showed a reduced threshold for pain (3.7 kg/cm(2) versus 4. 45 kg/cm2, p = 0.005). Control group presented increased bain activation when compared to IMP group in the following areas: thalamus (p = 0.00001), precentral gyrus (p = 0.0004) and middle frontal gyrus (p = 0.03). In intragroup analysis, IMP group showed greater brain activation during the unpredictable stimuli of the variable pain stage, especially in the lingual gyrus (p = 0.0001), frontal lobe (p = 0.0001), temporal gyrus (p = 0.0001) and precentral gyrus (p = 0.03), when compared to predictable stimulus of fixed pain. The same intragroup analysis with the control group showed greater activation during the unpredictable stimuli in regions of the precentral gyrus (p = 0.0001), subcallosal area (p = 0.0001), right and left occipital fusiform gyrus (p = 0.0001; (p = 0.0007), middle gyrus (p = 0.01) and precuneus p = (0.02). Conclusion: Adolescents with idiopathic musculoskeletal pain (IMP) tend to request higher brain function in cognitive-emotional areas when interpreting unpredictable sensory-perceptual situations. Therefore, it is assumed that this difference in pain processing in adolescents with IMP make the subjective experience of pain something more intense and unpleasant.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Pediat, Researcher Rheumatol Sect, Sao Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Brain Inst, Sao Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Dept Diagnost Imaging, Sao Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Brain Inst, Sao Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Sao Paulo, Brazil
dc.description.affiliationUniv Minho, Braga, Portugal
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Medicina, Dept Pediat, Pediat Rheumatol Unit, Rua Borges Lagoa 802,Vila Clementino, BR-04038002 Sao Paulo, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Dept Pediat, Rua Borges Lagoa 802,Vila Clementino, BR-04038002 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Pediat, Researcher Rheumatol Sect, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Medicina, Dept Pediat, Pediat Rheumatol Unit, Rua Borges Lagoa 802,Vila Clementino, BR-04038002 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipHospital Israelita Albert Einstein
dc.description.sponsorshipCAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1186/s12969-017-0209-6
dc.identifier.citationPediatric Rheumatology. London, v. 15, p. -, 2017.
dc.identifier.doi10.1186/s12969-017-0209-6
dc.identifier.fileWOS000415122500001.pdf
dc.identifier.issn1546-0096
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58175
dc.identifier.wosWOS:000415122500001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofPediatric Rheumatology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMusculoskeletal painen
dc.subjectMagnetic resonance imagingen
dc.subjectPainen
dc.subjectFunctional neuroimagingen
dc.subjectAdolescentsen
dc.subjectJuvenile fibromyalgiaen
dc.titleFunctional resonance magnetic imaging (fMRI) in adolescents with idiopathic musculoskeletal pain: a paradigm of experimental painen
dc.typeinfo:eu-repo/semantics/article
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