Effectiveness of an aquatic exercise program and low-level laser therapy on articular cartilage in an experimental model of osteoarthritis in rats

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dc.contributor.authorMilares, Luiz Paulo [UNIFESP]
dc.contributor.authorAssis, Livia [UNIFESP]
dc.contributor.authorSiqueira, Amanda [UNIFESP]
dc.contributor.authorClaudino, Vitoria [UNIFESP]
dc.contributor.authorDomingos, Heloisa [UNIFESP]
dc.contributor.authorAlmeida, Thais [UNIFESP]
dc.contributor.authorTim, Carla [UNIFESP]
dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.date.accessioned2019-07-22T15:46:49Z
dc.date.available2019-07-22T15:46:49Z
dc.date.issued2016
dc.description.abstractObjective: The aim of this study was to evaluate the effects of an aquatic exercise program and low-level laser therapy (LLLT) (associated or not) on degenerative modifications and inflammatory mediators on the articular cartilage using an experimental model of knee OA. Method: Forty male Wistar rats were divided into 4 groups: knee OA – without treatment (OA); OA plus exercise program group (OAE); OA plus LLLT (OAL); OA plus exercise program associated with LLLT (OAEL). Trained rats performed a water-jumping program carrying a load equivalent to 50-80 % of their body mass strapped to their chest. The laser irradiation was used either as the only method or after the exercise training had been performed, at 2 points contact mode (medial and lateral side of the left joint). The treatments started 4 weeks after the surgery, 3 days/week for 8 weeks. Results: The results revealed that all treated groups (irradiated or not) exhibited a better pattern of tissue organization, with less fibrillation and irregularities along the articular surface and improved chondrocytes organization. Also, a lower cellular density and structural damage (OARSI score) and higher thickness values were observed in all treated groups. Additionally, OAE and OAEL showed a reduced expression in IL-1β and caspase-3 as compared with OA. Furthermore, a statistically lower MMP-13 expression was only observed in OAEL as compared with OA. Conclusion: These results suggest that aquatic exercise program and LLLT were effective in preventing cartilage degeneration. Also, physical exercise program presented anti-inflammatory effects in the knees in OA rats.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, Santos, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biosci, Santos, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2012-20145-0
dc.format.extent398-407
dc.identifierhttps://dx.doi.org/10.1080/03008207.2016.1193174
dc.identifier.citationConnective Tissue Research. Philadelphia, v. 57, n. 5, p. 398-407, 2016.
dc.identifier.doi10.1080/03008207.2016.1193174
dc.identifier.issn0300-8207
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/51097
dc.identifier.wosWOS:000383444600007
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAquatic exerciseen
dc.subjectArticular cartilageen
dc.subjectKnee osteoarthritisen
dc.subjectLow-level laser therapyen
dc.subjectRehabilitationen
dc.titleEffectiveness of an aquatic exercise program and low-level laser therapy on articular cartilage in an experimental model of osteoarthritis in ratsen
dc.typeinfo:eu-repo/semantics/article
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