Analgesia and c-Fos expression in the periaqueductal gray induced by electroacupuncture at the Zusanli point in rats

Página do item simplificado
dc.contributor.authorMedeiros, M. A. de
dc.contributor.authorCanteras, N. S.
dc.contributor.authorSuchecki, D.
dc.contributor.authorMello, LEAM
dc.contributor.institutionUniv Fed Rural Rio de Janeiro
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T12:33:51Z
dc.date.available2016-01-24T12:33:51Z
dc.date.issued2003-05-30
dc.description.abstractThe need to use anaesthetised or restrained animals in acupuncture research in laboratory animals may represent a confounding variable, since both anaesthesia and stress alter the pain threshold and the activity of pain-related brain areas. in the current study we assessed the participation of the periaqueductal gray (PAG) in electroacupuncture's (EA) analgesic effects applied to the Zusanli point (36S) under carefully controlled stress conditions. Repeated immobilisation protocols (6 days, 1 h/day and 13 days, 2 h/day) were used to diminish the influence of acute immobilisation stress on c-Fos expression and analgesia (tail-flick test) induced by electroacupuncture on the 36S point (EA36S). Animals submitted to immobilisation alone (IMMO) or to electroacupuncture (100 Hz, 2-4 V, faradic wave) on a non-point region (EANP) were compared with animals submitted to electroacupuncture on the 36S point. in animals not previously submitted to repeated immobilisation, electroacupuncture on the 36S point induced analgesia and c-Fos expression in the PAG was not different from that induced by electroacupuncture at a non-acupuncture point. in animals submitted to repeated immobilisation (repeated immobilisation for 6 days or repeated immobilisation for 13 days), however, electroacupuncture on point 36S led to higher levels of analgesia and c-Fos expression, specifically in the ventrolateral PAG (v1PAG), as compared with animal groups subjected only to immobilisation or to electroacupuncture on a non-point. Our findings endorse previous results, and point to a specific part of the PAG involved in the effects of electroacupuncture at the Zusanli point. (C) 2003 Elsevier Science B.V. All rights reserved.en
dc.description.affiliationUniv Fed Rural Rio de Janeiro, Dept Physiol Sci IB, BR-23851970 Seropedica, RJ, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Physiol & Biophys, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent196-204
dc.identifierhttp://dx.doi.org/10.1016/S0006-8993(03)02479-X
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 973, n. 2, p. 196-204, 2003.
dc.identifier.doi10.1016/S0006-8993(03)02479-X
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27256
dc.identifier.wosWOS:000183025100006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectelectroacupuncture pointen
dc.subjectacupuncture non-pointen
dc.subjectc-fos-immunohistochemistryen
dc.subjecttail-flick testen
dc.subjectanalgesiaen
dc.subjectperiaqueductal grayen
dc.titleAnalgesia and c-Fos expression in the periaqueductal gray induced by electroacupuncture at the Zusanli point in ratsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos