Effects of carbohydrate and glutamine supplementation on oral mucosa immunity after strenuous exercise at high altitude: a double-blind randomized trial

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dc.citation.issue7]
dc.citation.volume9]
dc.contributor.authorCaris, Aline Venticinque [UNIFESP]
dc.contributor.authorSilva, Edgar Tavares da [UNIFESP]
dc.contributor.authorSantos, Samile Amorim dos [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.coverageBasel
dc.date.accessioned2020-06-26T16:30:28Z
dc.date.available2020-06-26T16:30:28Z
dc.date.issued2017
dc.description.abstractThis study analyzed the effects of carbohydrate and glutamine supplementation on salivary immunity after exercise at a simulated altitude of 4500 m. Fifteen volunteers performed exercise of 70% of VO2peak until exhaustion and were divided into three groups: hypoxia placebo, hypoxia 8% maltodextrin (200 mL/20 min), and hypoxia after six days glutamine (20 g/day) and 8% maltodextrin (200 mL/20 min). All procedures were randomized and double-blind. Saliva was collected at rest (basal), before exercise (pre-exercise), immediately after exercise (post-exercise), and two hours after exercise. Analysis of Variance (ANOVA) for repeated measures and Tukey post hoc test were performed. Statistical significance was set at p < 0.05. SaO(2)% reduced when comparing baseline vs. pre-exercise, post-exercise, and after recovery for all three groups. There was also a reduction of SaO(2)% in pre-exercise vs. post-exercise for the hypoxia group and an increase was observed in pre-exercise vs. recovery for both supplementation groups, and between post-exercise and for the three groups studied. There was an increase of salivary flow in post-exercise vs. recovery in Hypoxia + Carbohydrate group. Immunoglobulin A (IgA) decreased from baseline vs. post-exercise for Hypoxia + Glutamine group. Interleukin 10 (IL-10) increased from post-exercise vs. after recovery in Hypoxia + Carbohydrate group. Reduction of tumor necrosis factor alpha (TNF-alpha) was observed from baseline vs. post-exercise and after recovery for the Hypoxia + Carbohydrate group a lower concentration was observed in pre-exercise vs. post-exercise and recovery. TNF-alpha had a reduction from baseline vs. post-exercise for both supplementation groups, and a lower secretion between baseline vs. recovery, and pre-exercise vs. post-exercise for Hypoxia + Carbohydrate group. Five hours of hypoxia and exercise did not change IgA. Carbohydrates, with greater efficiency than glutamine, induced anti-inflammatory responses.en
dc.description.abstracten
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, BR-04032020 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, BR-11015020 Santos, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, BR-04032020 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biosci, BR-11015020 Santos, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttps://dx.doi.org/10.3390/nu9070692]
dc.identifier.citationNutrients. Basel, v. 9, n. 7, p. -, 2017.
dc.identifier.doi10.3390/nu9070692
dc.identifier.fileWOS000406679700049.pdf
dc.identifier.issn2072-6643
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53554
dc.identifier.wosWOS:000406679700049
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofNutrients
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSupplementationen
dc.subjectCarbohydrateen
dc.subjectHypoxiaen
dc.subjectPhysical exerciseen
dc.subjectGlutamineen
dc.subjectHigh altitudeen
dc.subjectInnate immune responseen
dc.subjectOral mucosal immunityen
dc.titleEffects of carbohydrate and glutamine supplementation on oral mucosa immunity after strenuous exercise at high altitude: a double-blind randomized trialen
dc.typeinfo:eu-repo/semantics/article
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