Encapsulation study of citalopram and risperidone into nanostructured silica SBA-15 for in vitro release evaluation

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dc.citation.issue2
dc.citation.volume127
dc.contributor.authorTanaka, Magali Naomi [UNIFESP]
dc.contributor.authorSoares Santos, Solange Teixeira [UNIFESP]
dc.contributor.authorGouveia, Marize
dc.contributor.authordos Santos Filho, Mery
dc.contributor.authorCosentino, Ivana Conte
dc.contributor.authorBarbosa Neto, Jair Borges
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMatos, Jivaldo do Rosario
dc.contributor.authorMercuri, Lucildes Pita [UNIFESP]
dc.coverageDordrecht
dc.date.accessioned2020-07-17T14:03:06Z
dc.date.available2020-07-17T14:03:06Z
dc.date.issued2017
dc.description.abstractOrdered mesoporous silica, SBA-15, presents non-toxic natureen
dc.description.abstracthigh pore volume and high surface areaen
dc.description.abstractthermal, hydrothermal and mechanical stabilities. These features may enable its use as a carrier for commonly prescribed drugs in psychiatric practice: citalopram (CIT) and risperidone (RIS). Thermogravimetry/derivative thermogravimetry (TG/DTG) and ultraviolet and visible absorption spectrophotometry (UV-Vis) were used to determine drug quantity into/onto ECIT (CIT encapsulated into SBA-15), ERIS (RIS encapsulated into SBA-15), MCIT (mixture of CIT with SBA-15) and MRIS (mixture of RIS with SBA-15). All materials were characterized through: TG/DTG, differential scanning calorimetry, elemental analysis, Fourier transform infrared absorption spectrophotometry and nitrogen adsorption-desorption. A general solvent-based method for loading these psychoactive drugs into non-functionalized SBA-15 showed to retard their liberation in simulated gastric and intestinal media when compared to physical mixtures performance. It is expected that the functionalization of this nanostructured silica may increasingly extend the dissolution of CIT and RIS after encapsulation process, leading to application in controlled release systems.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psicobiol, Escola Paulista Med, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, Inst Ciencias Ambientais Quim & Farmaceut, BR-09913030 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Ciencias Farmaceut, BR-05513970 Sao Paulo, Brazil
dc.description.affiliationUniv Santa Cecilia, Inst Super Educ Santa Cecilia, Dept Engn, BR-11045907 Sao Paulo, Brazil
dc.description.affiliationInst Pesquisas Energet & Nucl, Ctr Ciencia & Tecnol Mat, BR-05508900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Med, BR-04023061 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Lab Anal Term Prof Dr Ivo Giolito, Inst Quim, BR-05513970 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psicobiol, Escola Paulista Med, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, Inst Ciencias Ambientais Quim & Farmaceut, BR-09913030 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1725-1732
dc.identifierhttp://dx.doi.org/10.1007/s10973-016-5995-4
dc.identifier.citationJournal Of Thermal Analysis And Calorimetry. Dordrecht, v. 127, n. 2, p. 1725-1732, 2017.
dc.identifier.doi10.1007/s10973-016-5995-4
dc.identifier.issn1388-6150
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55166
dc.identifier.wosWOS:000394142200057
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal Of Thermal Analysis And Calorimetry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDrug deliveryen
dc.subjectOrdered mesoporous silicaen
dc.subjectControlled releaseen
dc.subjectSolvent-based loadingen
dc.titleEncapsulation study of citalopram and risperidone into nanostructured silica SBA-15 for in vitro release evaluationen
dc.typeinfo:eu-repo/semantics/article
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