Partial Replacement of omega-6 Fatty Acids With Medium-Chain Triglycerides, but Not Olive Oil, Improves Colon Cytokine Response and Damage in Experimental Colitis

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dc.contributor.authorBertevello, Pedro L.
dc.contributor.authorDe Nardi, Leticia
dc.contributor.authorTorrinhas, Raquel S.
dc.contributor.authorLogullo, Angela F. [UNIFESP]
dc.contributor.authorWaitzberg, Dan L.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:27Z
dc.date.available2016-01-24T14:27:27Z
dc.date.issued2012-07-01
dc.description.abstractBackground: Soybean oil is rich in omega-6 fatty acids, which are associated with higher incidence and more severe cases of inflammatory bowel diseases. the authors evaluated whether partial replacement of soybean oil by medium-chain triglycerides (MCTs) or olive oil influenced the incidence and severity of experimental ulcerative colitis by using different parenteral lipid emulsions (LEs). Methods: Wistar rats (n = 40) were randomized to receive parenteral infusion of the following LE: 100% soybean oil (SO), 50% MCT mixed with 50% soybean oil (MCT/SO), 80% olive oil mixed with 20% soybean oil (OO/SO), or saline (CC). After 72 hours of infusion, acetic acid experimental colitis was induced. After 24 hours, colon histology and cytokine expression were analyzed. Results: SO was not significantly associated with overall tissue damage. MCT/SO was not associated with necrosis (P < .005), whereas OO/SO had higher frequencies of ulcer and necrosis (P < .005). SO was associated with increased expression of interferon-gamma (P = .005) and OO/SO with increased interleukin (IL)-6 and decreased tumor necrosis factor-alpha expression (P < .05). MCT/SO appeared to decrease IL-1 (P < .05) and increase IL-4 (P < .001) expression. Conclusions: Parenteral SO with high concentration of omega-6 fatty acids was not associated with greater tissue damage in experimental colitis. SO partial replacement with MCT/SO decreased the frequency of histological necrosis and favorably modulated cytokine expression in the colon; however, replacement with OO/SO had unfavorable effects. (JPEN J Parenter Enteral Nutr. 2012; 36: 442-448)en
dc.description.affiliationUniv São Paulo, Sch Med FMUSP, Dept Gastroenterol, Digest Surg Div LIM 35, BR-01243906 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Sch Med UNIFESP EPM, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Sch Med UNIFESP EPM, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDCNPq: 140925/00-7
dc.description.sponsorshipIDFAPESP: 97/07971-70
dc.format.extent442-448
dc.identifierhttp://dx.doi.org/10.1177/0148607111421788
dc.identifier.citationJournal of Parenteral and Enteral Nutrition. Thousand Oaks: Sage Publications Inc, v. 36, n. 4, p. 442-448, 2012.
dc.identifier.doi10.1177/0148607111421788
dc.identifier.issn0148-6071
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35079
dc.identifier.wosWOS:000305487500011
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofJournal of Parenteral and Enteral Nutrition
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjectmedium-chain triglyceridesen
dc.subjectolive oilen
dc.subjectsoybean oilen
dc.subjectcolitisen
dc.subjectlipid emulsionen
dc.subjectparenteral nutritionen
dc.titlePartial Replacement of omega-6 Fatty Acids With Medium-Chain Triglycerides, but Not Olive Oil, Improves Colon Cytokine Response and Damage in Experimental Colitisen
dc.typeinfo:eu-repo/semantics/article
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