Ultrastructural and biochemical changes of the medial pterygoid muscle induced by unilateral exodontia

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dc.contributor.authorBazan, Emmanuel [UNIFESP]
dc.contributor.authorMardegan Issa, Joao Paulo
dc.contributor.authorWatanabe, Ii-sei
dc.contributor.authorAlberto Mandarim-de-Lacerda, Carlos
dc.contributor.authorAparecida Del Bel, Elaine
dc.contributor.authorIyomasa, Mamie Mizusaki
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)
dc.date.accessioned2016-01-24T13:51:31Z
dc.date.available2016-01-24T13:51:31Z
dc.date.issued2008-07-01
dc.description.abstractThe aim of the present study was to investigate the histological, biochemical and ultrastructural effects of occlusal alteration induced by unilateral exodontia on medial pterygoid muscle in guinea pigs, Cavia porcellus. Thirty (n = 30) male guinea pigs (450 g) were divided into two groups: experimental-animals submitted to exodontia of the left upper molars, and sham-operated were used as control. the duration of the experimental period was 60 days. Medial pterygoid muscles from ipsilateral and contralateral side were analyzed by histological (n = 10), histochernical (n = 10), and ultrastructural (n = 10) methods. the data were submitted to statistical analysis. When the ipsilateral side was compared to the control group, it showed a significantly shorter neuromuscular spindle length (P < 0.05), lower oxidative metabolic activity, and microvessel constriction, in spite of the capillary volume and surface density were not significantly different (P > 0.05). in the contralateral side, the neuromuscular spindles showed significantly shorter length (P < 0.05), the fibers reflected a higher oxidative capacity, the blood capillaries showed endothelial cell emitting slender sprouting along the pre-existing capillary, and significantly higher blood capillary surface density, and volume density (V-v = 89% Mann-Whitney test, P < 0.05). This finding indicated a complex morphological and functional medial pterygoid muscle adaptation to occlusal alteration in this experimental model. Considering that neuromuscular spindles are responsible for the control of mandibular positioning and movements, the professional should consider if these changes interfere in the success of clinical procedures in medical field involving stomatognathic structures. (c) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Fac Dent, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Fac Med, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, São Paulo, Brazil
dc.description.affiliationUniv State Rio de Janeiro UERJ, Biomed Ctr, Rio de Janeiro, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Fac Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent536-543
dc.identifierhttp://dx.doi.org/10.1016/j.micron.2007.07.006
dc.identifier.citationMicron. Oxford: Pergamon-Elsevier B.V., v. 39, n. 5, p. 536-543, 2008.
dc.identifier.doi10.1016/j.micron.2007.07.006
dc.identifier.issn0968-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30764
dc.identifier.wosWOS:000257532400004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMicron
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectmedial pterygoid muscleen
dc.subjecttransmission electron microscopyen
dc.subjecthistochemistryen
dc.subjectneuromuscular spindleen
dc.subjectblood capillaryen
dc.titleUltrastructural and biochemical changes of the medial pterygoid muscle induced by unilateral exodontiaen
dc.typeinfo:eu-repo/semantics/article
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