c-erbB-2 oncoprotein in gastric carcinoma: correlation with clinical stage and prognosis
Data
2001-10-01
Autores
Oshima, Celina Tizuko Fujiyama 
Lanzoni, Valeria Pereira
Forones, Nora Manoukian
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
The aim of this study was to investigate the expression of the oncogene c-erbB-2 in gastric tumors. Immunohistochemical study of the expression of c-erbB-2 was performed in formalin-fixed, paraffin-embedded sections from 82 gastric adenocarcinomas using polyclonal antibody. c-erbB-2-positive immunostaining was observed in 37 (45%) tumors. Positive staining was detected in 63% of well differentiated, 46% of moderately differentiated and 80% of papillary adenocarcinomas. In poorly differentiated adenocarcinomas, positivity for c-erbB-2 was observed in 21%. According to the Lauren classification, a higher frequency of c-erbB-2 positive staining was observed in intestinal type tumors (70%). During the follow-up period 43% of the patients with c-erbB-2 oncoprotein-negative tumors and 45% of the patients with c-erbB-2 oncoprotein-positive tumors died. There was no significant association between c-erbB-2 staining and sex, age, clinical stage, tumor grade, histological type or survival rates. In conclusion, almost half of the gastric cancers were positive for c-erbB-2. Nonetheless, the expression of c-erbB-2 oncoprotein did not play a role in prognosis.
Descrição
Citação
International Journal Of Biological Markers. Milan: Wichtig Editore, v. 16, n. 4, p. 250-254, 2001.