High-resolution proteomic profiling of spider venom: expanding the toxin diversity of Phoneutria nigriventer venom

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dc.citation.issue3
dc.citation.volume48
dc.contributor.authorLiberato, Tarcisio [UNIFESP]
dc.contributor.authorPaolo Troncone, Lanfranco Ranieri
dc.contributor.authorYamashiro, Edson T.
dc.contributor.authorSerrano, Solange M. T.
dc.contributor.authorZelanis, Andre [UNIFESP]
dc.coverageWien
dc.date.accessioned2020-08-21T17:00:14Z
dc.date.available2020-08-21T17:00:14Z
dc.date.issued2016
dc.description.abstractHere we present a proteomic characterization of Phoneutria nigriventer venom. A shotgun proteomic approach allowed the identification, for the first time, of O-glycosyl hydrolases (chitinases) in P. nigriventer venom. The electrophoretic profiles under nonreducing and reducing conditions, and protein identification by mass spectrometry, indicated the presence of oligomeric toxin structures in the venom. Complementary proteomic approaches allowed for a qualitative and semi-quantitative profiling of P. nigriventer venom complexity, expanding its known venom proteome diversity.en
dc.description.affiliationInst Butantan, Farmacol Lab, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Lab Prote Func, Dept Ciencia & Tecnol, ICT UNIFESP, Campus Sao Jose dos Campos,Rua Talim 330, BR-12231280 Sao Paulo, SP, Brazil
dc.description.affiliationInst Butantan, Lab Especial Toxinol Aplicada, Ctr Toxins Immune Response & Cell Signaling CeTIC, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Lab Prote Func, Dept Ciencia & Tecnol, ICT UNIFESP, Campus Sao Jose dos Campos,Rua Talim 330, BR-12231280 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 11/08514-8
dc.description.sponsorshipIDFAPESP: 13/07467-1
dc.description.sponsorshipIDFAPESP: 02/04545-7
dc.format.extent901-906
dc.identifierhttp://dx.doi.org/10.1007/s00726-015-2151-6
dc.identifier.citationAmino Acids. Wien, v. 48, n. 3, p. 901-906, 2016.
dc.identifier.doi10.1007/s00726-015-2151-6
dc.identifier.issn0939-4451
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57917
dc.identifier.wosWOS:000370817900022
dc.language.isoeng
dc.publisherSpringer Wien
dc.relation.ispartofAmino Acids
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPhoneutria nigriventeren
dc.subjectProteomeen
dc.subjectSpider venomen
dc.subjectChitinaseen
dc.titleHigh-resolution proteomic profiling of spider venom: expanding the toxin diversity of Phoneutria nigriventer venomen
dc.typeinfo:eu-repo/semantics/article
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