Acoustic rhinometry in nasal provocation tests in children and adolescents

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dc.contributor.authorWandalsen, G. F. [UNIFESP]
dc.contributor.authorMendes, A. L. [UNIFESP]
dc.contributor.authorMatsumoto, F. [UNIFESP]
dc.contributor.authorSole, D. [UNIFESP]
dc.date.accessioned2019-01-21T10:29:54Z
dc.date.available2019-01-21T10:29:54Z
dc.date.issued2016
dc.description.abstractObjectives: To standardize acoustic rhinometry (AR) in nasal provocation tests (NPTs) with histamine in children and adolescents. Patients and Methods: We performed a cross-sectional validation to compare AR with anterior active rhinomanometry (AAR) during histamine NPT in 20 children and adolescents with persistent allergic rhinitis and 20 controls. Changes in total nasal resistance (AAR) were compared with changes in nasal volume in the first 5 cm (V5). Results: Compared with controls, patients with rhinitis had significantly higher mean total nasal resistance (0.34 Pa/cm(3)/s vs 0.21 Pa/cm(3)/sen
dc.description.abstractP=.01) and lower mean V5 values (8.20 cm(3) vs 9.24 cm(3)en
dc.description.abstractP=.04) at baseline. The mean histamine concentration necessary to increase total nasal resistance by at least 100% was significantly lower in the rhinitis group than in the control group (0.72 mg/mL vs 2.4 mg/mLen
dc.description.abstractP<.001). At the end of the NPT a mean increase of 126% in total nasal resistance and a mean decrease of 24.3% in V5 were observed in the rhinitis group. When compared with the AAR criteria, the highest sensitivity and specificity values were observed for a cutoff represented by a 19%-21% drop in V5. Conclusions: We found AR to be a feasible and sensitive tool for monitoring nasal response in children and adolescents undergoing histamine NPT. The best AR cutoff for ending the NPT was a 19%-21% drop in V5.en
dc.description.affiliationDivision of Allergy and Clinical Immunology, Department of Pediatrics, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
dc.description.affiliationUnifespDivision of Allergy and Clinical Immunology, Department of Pediatrics, Federal University of São Paulo (UNIFESP), Rua Otonis 725, BR-04025002 Sao Paulo, SP, Brazil.
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCAPES
dc.description.sponsorshipIDThis study was funded FAPESP and CAPES.
dc.format.extent156-160
dc.identifierhttp://dx.doi.org/10.18176/jiaci.0036
dc.identifier.citationJournal Of Investigational Allergology And Clinical Immunology. Barcelona, v. 26, n. 3, p. 156-160, 2016.
dc.identifier.doi10.18176/jiaci.0036
dc.identifier.issn1018-9068
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49461
dc.identifier.wosWOS:000379704800002
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofJournal Of Investigational Allergology And Clinical Immunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRhinitisen
dc.subjectNasal Provocation Testsen
dc.subjectHistamineen
dc.subjectAcoustic Rhinometryen
dc.subjectRhinomanometryen
dc.subjectNasal Cavityen
dc.subjectAirway ResistanceAllergic Rhinitisen
dc.subjectChallengeen
dc.subjectResistanceen
dc.subjectPatencyen
dc.titleAcoustic rhinometry in nasal provocation tests in children and adolescentsen
dc.typeinfo:eu-repo/semantics/article
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