Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats

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dc.contributor.authorBotelho, Marco A.
dc.contributor.authorBarros, Gisele
dc.contributor.authorQueiroz, Dinalva B.
dc.contributor.authorCarvalho, Celso Felicio
dc.contributor.authorGouvea, Julia
dc.contributor.authorPatrus, Lia
dc.contributor.authorBannet, Mariane
dc.contributor.authorPatrus, Danile
dc.contributor.authorRego, Amalia
dc.contributor.authorSilva, Ivaldo [UNIFESP]
dc.contributor.authorCampus, Guglielmo
dc.contributor.authorAraujo-Filho, Irami
dc.date.accessioned2018-07-26T17:30:20Z
dc.date.available2018-07-26T17:30:20Z
dc.date.issued2016
dc.description.abstractLippia sidoides Cham (Verbenaceae) is largely distributed in the northeastern region of Brazil. It is popularly known as Alecrim-pimenta '. Recent studies have shown that some species of Lippia have interesting pharmacological activities. This study aimed to evaluate the effect of a nanostructured thymol gel (TG) 1.2mg/g on acute phase of ligature-induced periodontitis model [acute periodontal disease (APD)] in rats. APD was induced in 24 Wistar rats subjected to ligature placement on left molars in maxillae. Animals were treated with TG, immediately after APD induction. Saline-based gel was utilized as negative control and diethylammonium diclofenac gel 10mg/g was used as positive control. Animals were randomly assigned into the groups. The periodontium and the surrounding gingiva were examined at histopathology, as well as the neutrophil influx into the gingiva was assayed using myeloperoxidase activity levels by ELISA method. TG treatment reduced tissue lesion at histopathology coupled to decreased myeloperoxidase activity production in gingival tissue when compared with the saline gel control group (p < 0.05). The TG gel was able to provide a significant myeloperoxidase decreasing in gingiva tissue confirming to be effective in reducing gingival inflammation in this model. Copyright (c) 2015 John Wiley & Sons, Ltd.en
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Surg, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUniv Potiguar, Post Graduat Program Biotechnol, Natal, RN, Brazil
dc.description.affiliationUniv Anhembi Morumbi, Sch Hlth, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Gynaecol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sassari, Sch Dent, Dept Surg Microsurg & Med Sci, I-07100 Sassari, Italy
dc.description.affiliationUnifespDepartament of Gynecology, Federal University of São PauloSao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIFCE Edital PRO INFRA
dc.description.sponsorshipIDCNPq; 310483/2012-3
dc.format.extent152-159
dc.identifierhttp://dx.doi.org/10.1002/ptr.5516
dc.identifier.citationPhytotherapy Research. Hoboken, v. 30, n. 1, p. 152-159, 2016.
dc.identifier.doi10.1002/ptr.5516
dc.identifier.issn0951-418X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/46055
dc.identifier.wosWOS:000367919300021
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofPhytotherapy Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectLippia sidoidesen
dc.subjectperiodontitisen
dc.subjectVerbenaceaen
dc.subjectthymolen
dc.subjectnanotechnologyen
dc.subjectBrazilian plantsLigature-Induced Periodontitisen
dc.subjectHormone Replacement Therapyen
dc.subjectAlveolar Bone-Resorptionen
dc.subjectEssential Oil Mouthrinseen
dc.subjectGingivitisen
dc.subjectCarvacrolen
dc.subjectMiceen
dc.titleNanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured Thymol Gel from Lippia sidoides in Acute Periodontitis in Ratsen
dc.typeinfo:eu-repo/semantics/article
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