CA1 inactivation impairs episodic-like memory in rats

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dc.citation.volume145
dc.contributor.authorDrieskens, Davi Carvalho
dc.contributor.authorNeves, Livia Rodrigues
dc.contributor.authorPugliane, Karen Cristina
dc.contributor.authorMontenegro Bento de Souza, Ingrid Brasilino
dc.contributor.authorLima, Alvaro da Costa [UNIFESP]
dc.contributor.authorda Silva Stiebbe Salvadori, Mirian Graciela
dc.contributor.authorRibeiro, Alessandra Mussi [UNIFESP]
dc.contributor.authorSilva, Regina Helena [UNIFESP]
dc.contributor.authorBarbosa, Flavio Freitas
dc.coverageSan Diego
dc.date.accessioned2020-09-01T13:21:25Z
dc.date.available2020-09-01T13:21:25Z
dc.date.issued2017
dc.description.abstractEpisodic memory was initially believed to be unique to humans. However, studies demonstrate that non-human species discriminate items based on the triad what, where and when. Here we addressed the role of the dorsal hippocampal subfield CA1 in an integrative what-where-when task in Wistar rats. We performed bilateral inactivation of dorsal CA1 with the GABAA agonist muscimol previously to the task. As expected, sham-operated animals recollected an integrative memory for objects (what), their places (where) and temporal order (when). However, the inactivation of CA1 impaired the performance of the three components of episodic-like memory. In addition, total time of objects exploration and distance traveled were not different between groups, indicating that rats had similar levels of motivation, thus, alterations in exploration does not account for impaired locomotor performance. Altogether, our data provides evidence that CA1 plays an important role in episodic-like memory. (C) 2017 Elsevier Inc. All rightsen
dc.description.affiliationUniv Fed Paraiba, Dept Psychol, Memory & Cognit Studies Lab, Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Inst Brain, Natal, RN, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Biophys & Pharmacol, Behav Pharmacol Lab, Natal, RN, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, Behav Neurosci Lab, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, Lab Neurosci & Bioprospecting Nat Prod, Santos, SP, Brazil
dc.description.affiliationUniv Fed Paraiba, Lab Psychopharmacol, Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pharmacol, Behav Neurosci Lab, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biosci, Lab Neurosci & Bioprospecting Nat Prod, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipIDCNPq: 014/2013 - Universal
dc.format.extent28-33
dc.identifierhttp://dx.doi.org/10.1016/j.nlm.2017.08.008
dc.identifier.citationNeurobiology Of Learning And Memory. San Diego, v. 145, p. 28-33, 2017.
dc.identifier.doi10.1016/j.nlm.2017.08.008
dc.identifier.issn1074-7427
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58247
dc.identifier.wosWOS:000417115800004
dc.language.isoeng
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofNeurobiology Of Learning And Memory
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpisodic-like memoryen
dc.subjectCA1en
dc.subjectMuscimolen
dc.subjectWistar ratsen
dc.titleCA1 inactivation impairs episodic-like memory in ratsen
dc.typeinfo:eu-repo/semantics/article
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