Renal hemodynamic response to erythropoietin-induced polycythemia in 5/6 nephrectomised rats is different from normal rats

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dc.contributor.authorPaixao, Ana Durce Oliveira da [UNIFESP]
dc.contributor.authorFerreira, Alice Teixeira [UNIFESP]
dc.contributor.authorOshiro, Maria Etsuko Miyamoto [UNIFESP]
dc.contributor.authorRazvickas, Clara Versolato [UNIFESP]
dc.contributor.authorBoim, Mirian Aparecida [UNIFESP]
dc.contributor.authorSchor, Nestor [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:22:31Z
dc.date.available2018-06-15T17:22:31Z
dc.date.issued1998-05-01
dc.description.abstractThe effects of recombinant human erythropoietin (rHuEPO)-induced polycythemia on renal function and glomerular hemodynamics were evaluated in Munich-Wistar rats (MW+EPO) before and after infusion of indomethacin; the rHuEPO effects on total renal function were also evaluated in 5/6 nephrectomized (CRF) MW and spontaneously hypertensive rats (MW-CRF+EPO and SHR-CRF+EPO, respectively). In normal MW rats, rHuEPO (300 IU/kg BW, 3 x /week, during 2 weeks) induced elevation in MAP, with maintenance of GFR, paralleled by superficial vasodilatation and elevation in SNGFR, suggesting cortical blood redistribution. These hemodynamic alterations induced by rHuEPO were blunted by indomethacin, suggesting a participation of the vasodilator prostaglandins in the renal compensatory mechanism of polycythemia. Elevation in MAP and reduction in GFR occurred in the MW+CRF+EPO group compared with the group receiving vehicle. In contrast, the SHR-CRF+EPO presented a reduction in MAP and maintenance of GFR, suggesting different rHuEPO effects depending on previous renal function and/or hypertensive state.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Div Nephrol, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Div Nephrol, BR-04023062 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent245-252
dc.identifierhttps://doi.org/10.1159/000020529
dc.identifier.citationExperimental Nephrology. Basel: Karger, v. 6, n. 3, p. 245-252, 1998.
dc.identifier.doi10.1159/000020529
dc.identifier.issn1018-7782
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43643
dc.identifier.wosWOS:000073968300010
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofExperimental Nephrology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.karger.com/Services/RightsPermissions
dc.subjecterythropoietinen
dc.subjectindomethacinen
dc.subjectspontaneously hypertensive ratsen
dc.subjectchronic renal failureen
dc.titleRenal hemodynamic response to erythropoietin-induced polycythemia in 5/6 nephrectomised rats is different from normal ratsen
dc.typeinfo:eu-repo/semantics/article
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