Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring

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dc.citation.issue1
dc.citation.volume11
dc.contributor.authorda Silva, Sergio Gomes [UNIFESP]
dc.contributor.authorde Almeida, Alexandre Aparecido [UNIFESP]
dc.contributor.authorFernandes, Jansen [UNIFESP]
dc.contributor.authorLopim, Glauber Menezes [UNIFESP]
dc.contributor.authorCabral, Francisco Romero
dc.contributor.authorScerni, Debora Amado [UNIFESP]
dc.contributor.authorde Oliveira-Pinto, Ana Virginia
dc.contributor.authorLent, Roberto
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.coverageSan Francisco
dc.date.accessioned2020-11-03T14:40:41Z
dc.date.available2020-11-03T14:40:41Z
dc.date.issued2016
dc.description.abstractClinical evidence has shown that physical exercise during pregnancy may alter brain development and improve cognitive function of offspring. However, the mechanisms through which maternal exercise might promote such effects are not well understood. The present study examined levels of brain-derived neurotrophic factor (BDNF) and absolute cell numbers in the hippocampal formation and cerebral cortex of rat pups born from mothers exercised during pregnancy. Additionally, we evaluated the cognitive abilities of adult offspring in different behavioral paradigms (exploratory activity and habituation in open field tests, spatial memory in a water maze test, and aversive memory in a step-down inhibitory avoidance task). Results showed that maternal exercise during pregnancy increased BDNF levels and absolute numbers of neuronal and non-neuronal cells in the hippocampal formation of offspring. No differences in BDNF levels or cell numbers were detected in the cerebral cortex. It was also observed that offspring from exercised mothers exhibited better cognitive performance in nonassociative (habituation) and associative (spatial learning) mnemonic tasks than did offspring from sedentary mothers. Our findings indicate that maternal exercise during pregnancy enhances offspring cognitive function (habituation behavior and spatial learning) and increases BDNF levels and cell numbers in the hippocampal formation of offspring.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Fisiol, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Mogi das Cruzes, Mogi das Cruzes, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Disciplina Neurol Expt, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Ciencias Biomed, Rio de Janeiro, RJ, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Fisiol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Disciplina Neurol Expt, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipInstituto Nacional de Neurociencia Translacional (INNT, Brazil)
dc.description.sponsorshipIDFAPESP: 09/06953-4
dc.description.sponsorshipIDFAPESP: 10/11353-3
dc.format.extent-
dc.identifierhttps://doi.org/10.1371/journal.pone.0147200
dc.identifier.citationPlos One. San Francisco, v. 11, n. 1, p. -, 2016.
dc.identifier.doi10.1371/journal.pone.0147200
dc.identifier.fileWOS000368628300071.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58689
dc.identifier.wosWOS:000368628300071
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleMaternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspringen
dc.typeinfo:eu-repo/semantics/article
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