Impaired glucose metabolism moderates the course of illness in bipolar disorder

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dc.citation.volume195
dc.contributor.authorMansur, Rodrigo Barbachan [UNIFESP]
dc.contributor.authorRizzo, Lucas Bortolotto [UNIFESP]
dc.contributor.authorSantos, Camila Mauricio [UNIFESP]
dc.contributor.authorAsevedo, Elson [UNIFESP]
dc.contributor.authorCunha, Graccielle Rodrigues da [UNIFESP]
dc.contributor.authorNoto, Mariane Nunes [UNIFESP]
dc.contributor.authorPedrini, Mariana [UNIFESP]
dc.contributor.authorZeni, Maiara [UNIFESP]
dc.contributor.authorCordeiro, Quirino [UNIFESP]
dc.contributor.authorMcIntyre, Roger S.
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-22T13:23:05Z
dc.date.available2020-07-22T13:23:05Z
dc.date.issued2016
dc.description.abstractBackground: The longitudinal course of bipolar disorder (BD) is highly heterogeneous, and is moderated by the presence of general medical comorbidities. This study aimed to investigate the moderating effects of impaired glucose metabolism (IGM) on variables of illness course and severity in a BD population. Methods: Fifty-five patients with BD were evaluated. All subjects were evaluated with respect to current and past psychiatric and medical disorders, as well as lifetime use of any medication. Body mass index (BMI) and metabolic parameters were obtained. IGM was operationalized as pre-diabetes or type 2 diabetes mellitus. Results: Thirty (54.5%) individuals had IGM. After adjustment for age, gender, ethnicity, alcohol use, smoking, BMI and past and current exposure to psychotropic medications, individuals with IGM, when compared to euglycemic participants, had an earlier age of onset (RR: 0.835, p=0.024), longer illness duration (RR: 1.754, p=0.007), a higher number of previous manic/hypomanic episodes (RR: 1.483, p=0.002) and a higher ratio of manic/hypomanic to depressive episodes (RR: 1.753, p=0.028). Moreover, we observed a moderating effect of IGM on the association between number of mood episodes and other variables of illness course, with the correlation between lifetime mood episodes and frequency of episodes being significantly greater in the IGM subgroup (RR: 1.027, p=0.029). All associations observed herein remained significant after adjusting for relevant confounding factors (e.g. age, alcohol and tobacco use, exposure to psychotropic agents, BMI). Limitations: Cross-sectional design, small sample size. Conclusions: Comorbid IGM may be a key moderator of illness progression in BD. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psychiat, LINC, Sao Paulo, Brazil
dc.description.affiliationUniv Toronto, Univ Hlth Network, MDPU, Toronto, ON, Canada
dc.description.affiliationUniv Tubingen, Dept Psychiat, Clin Psychiat & Psychotherapy, Tubingen, Germany
dc.description.affiliationVila Maria Outpatient Clin, Sao Paulo, Brazil
dc.description.affiliationISCMSP, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Psychiat, LINC, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent57-62
dc.identifierhttp://dx.doi.org/10.1016/j.jad.2016.02.002
dc.identifier.citationJournal Of Affective Disorders. Amsterdam, v. 195, p. 57-62, 2016.
dc.identifier.doi10.1016/j.jad.2016.02.002
dc.identifier.issn0165-0327
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56029
dc.identifier.wosWOS:000371257400007
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal Of Affective Disorders
dc.rightsAcesso restrito
dc.subjectBipolar disorderen
dc.subjectCourseen
dc.subjectProgressionen
dc.subjectImpaired glucose metabolismen
dc.subjectDiabetesen
dc.titleImpaired glucose metabolism moderates the course of illness in bipolar disorderen
dc.typeArtigo
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