Excitatory effects of nitric oxide within the rostral ventrolateral medulla of freely moving rats

Página do item simplificado
dc.contributor.authorPinge, Marli Cardoso Martins [UNIFESP]
dc.contributor.authorPassy, Izabel Baraldi [UNIFESP]
dc.contributor.authorLopes, Oswaldo Ubriaco [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:35:14Z
dc.date.available2018-06-15T17:35:14Z
dc.date.issued1997-09-01
dc.description.abstractThe aim of the present study was to examine the participation of NO in the rostral ventrolateral medulla (RVLM) of freely moving rats. We utilized NO donors and L-arginine, which were microinjected into the RVLM. Unilateral microinjection (100 nL) of 2.5 nmol sodium nitroprusside produced a biphasic response consisting of an initial, rapid increase in arterial pressure (AP) from 125+/-5 to 161+/-8 mm Hg (P<.01) and a second, long-lasting response with a progressive increase in AP (maximum Delta peak, 34+/-9 mm Hg; P<.01). Another NO donor, S-nitroso-N-acetylpenicillamine (SNAP; 2.5 nmol), also produced immediate hypertension from 118+/-5 mm Hg to 168+/-7 mm Hg (P<.01) but without the second, long-lasting response. L-Arginine (5, 24, and 140 nmol) produced a gradual increase in AP. L-Glutamate (5 nmol) microinjected into the RVLM produced an increase in AP from 122+/-9 mm Hg to 171+/-8 mm Hg (P<.01) and bradycardia from 342+/-10 to 315+/-8 beats/min. This AP response was significantly attenuated, from 115+/-7 to 128+/-9 mm Hg (P<.05), after microinjection of methylene blue (3 nmol) without alterations In heart rate. These results indicate that NO may have an excitatory effect on the RVLM of freely moving rats, probably in association with glutamatergic synapses via cGMP mechanisms.en
dc.description.affiliationUNIV FED SAO PAULO,DEPT FISIOL,ESCOLA PAULISTA MED,BR-04023060 SAO PAULO,SP,BRAZIL
dc.description.affiliationUnifespUNIV FED SAO PAULO,DEPT FISIOL,ESCOLA PAULISTA MED,BR-04023060 SAO PAULO,SP,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent704-707
dc.identifierhttps://doi.org/10.1161/01.HYP.30.3.704
dc.identifier.citationHypertension. Dallas: Amer Heart Assoc, v. 30, n. 3, p. 704-707, 1997.
dc.identifier.doi10.1161/01.HYP.30.3.704
dc.identifier.issn0194-911X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43846
dc.identifier.wosWOS:A1997XY88000033
dc.language.isoeng
dc.publisherAmer Heart Assoc
dc.relation.ispartofHypertension
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectamino acidsen
dc.subjectblood pressure, arterialen
dc.subjectbrainen
dc.subjectnitric oxideen
dc.subjectrostral ventrolateral medullaen
dc.titleExcitatory effects of nitric oxide within the rostral ventrolateral medulla of freely moving ratsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos