Impact of maternal food restriction on cold-induced thermogenesis in the offspring

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dc.contributor.authorLuz, J.
dc.contributor.authorGriggio, Mauro Antonio [UNIFESP]
dc.contributor.authorVieira, L. V.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:40Z
dc.date.available2016-01-24T12:33:40Z
dc.date.issued2003-01-01
dc.description.abstractFood restriction imposed during pregnancy usually leads to many alterations in the development of the conceptus. Some of these alterations can be reverted after birth by adequate nutritional rehabilitation, while there are others which are permanent. the aim of this article is to study the influence of maternal food restriction on offspring thermoregulation. Offspring of dams with food restriction during pregnancy (50%) were fed ad libitum after weaning. Rectal temperature was measured every 15 days from weaning to the 90th day of life. From the 60th to the 90th day the animals were either acclimated at 25 or 5degreesC. On the 90th day the animals were killed and their carcasses were processed for energy balance analysis and body composition determination. the results showed that animals from food-restricted mothers were not able to maintain body temperature for a longer period of time than the pups from control dams. Energy balance parameters and body composition did not show significant differences between rats from control and food-restriction mothers at the same environmental temperature. Thus, the results suggest that intrauterine food restriction may delay the development of the hypothalamus-thyroid axis which, in turn, may affect brown adipose tissue development leading to inefficient thermoregulation during neonatal life. Copyright (C) 2003 S. Karger AG, Basel.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent252-258
dc.identifierhttp://dx.doi.org/10.1159/000072309
dc.identifier.citationBiology of the Neonate. Basel: Karger, v. 84, n. 3, p. 252-258, 2003.
dc.identifier.doi10.1159/000072309
dc.identifier.issn0006-3126
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27107
dc.identifier.wosWOS:000185558900009
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofBiology of the Neonate
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.karger.com/Services/RightsPermissions
dc.subjectmaternal food restrictionen
dc.subjectthermoregulationen
dc.subjectbody temperatureen
dc.subjectcold-induced thermogenesisen
dc.subjectenergy expenditureen
dc.titleImpact of maternal food restriction on cold-induced thermogenesis in the offspringen
dc.typeinfo:eu-repo/semantics/article
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