Immunodominance: a new hypothesis to explain parasite escape and host/parasite equilibrium leading to the chronic phase of Chagas' disease?

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dc.contributor.authorRodrigues, Mauricio Martins [UNIFESP]
dc.contributor.authorAlencar, Bruna Cunha Gondim de [UNIFESP]
dc.contributor.authorClaser, Carla [UNIFESP]
dc.contributor.authorTzelepis, Fanny [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:39:07Z
dc.date.available2015-06-14T13:39:07Z
dc.date.issued2009-03-01
dc.description.abstractIntense immune responses are observed during human or experimental infection with the digenetic protozoan parasite Trypanosoma cruzi. The reasons why such immune responses are unable to completely eliminate the parasites are unknown. The survival of the parasite leads to a parasite-host equilibrium found during the chronic phase of chagasic infection in most individuals. Parasite persistence is recognized as the most likely cause of the chagasic chronic pathologies. Therefore, a key question in Chagas' disease is to understand how this equilibrium is established and maintained for a long period. Understanding the basis for this equilibrium may lead to new approaches to interventions that could help millions of individuals at risk for infection or who are already infected with T. cruzi. Here, we propose that the phenomenon of immunodominance may be significant in terms of regulating the host-parasite equilibrium observed in Chagas' disease. T. cruzi infection restricts the repertoire of specific T cells generating, in some cases, an intense immunodominant phenotype and in others causing a dramatic interference in the response to distinct epitopes. This immune response is sufficiently strong to maintain the host alive during the acute phase carrying them to the chronic phase where transmission usually occurs. At the same time, immunodominance interferes with the development of a higher and broader immune response that could be able to completely eliminate the parasite. Based on this, we discuss how we can interfere with or take advantage of immunodominance in order to provide an immunotherapeutic alternative for chagasic individuals.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Centro Interdisciplinar de Terapia Gênica
dc.description.affiliationUnifespUNIFESP, EPM, Centro Interdisciplinar de Terapia Gênica
dc.description.sourceSciELO
dc.description.sponsorshipMillennium Institute for Gene Therapy
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2006/1983-4||FAPESP: 2003/09675-9
dc.description.sponsorshipIDFAPESP: 2003/09672-0
dc.description.sponsorshipIDFAPESP: 2004/110106-6
dc.description.sponsorshipIDCNPq: 420067/2005-1
dc.description.sponsorshipIDCNPq: 307151/2006-9
dc.format.extent220-223
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2008005000054
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 42, n. 3, p. 220-223, 2009.
dc.identifier.doi10.1590/S0100-879X2008005000054
dc.identifier.fileS0100-879X2009000300001.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2009000300001
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4942
dc.identifier.wosWOS:000264200100001
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChagas' diseaseen
dc.subjectTrypanosoma cruzien
dc.subjectImmunodominanceen
dc.subjectMajor histocompatibility complexen
dc.titleImmunodominance: a new hypothesis to explain parasite escape and host/parasite equilibrium leading to the chronic phase of Chagas' disease?en
dc.typeinfo:eu-repo/semantics/article
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