The protective effect of Canova homeopathic medicine in cyclophosphamide-treated non-human primates

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dc.contributor.authorLeal, Mariana Ferreira [UNIFESP]
dc.contributor.authorAntunes, Lusania Maria Greggi
dc.contributor.authorLamarao, Maria Fernanda Vita
dc.contributor.authorSilva, Carla Elvira Araujo da
dc.contributor.authorSilva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.contributor.authorAssumpcao, Paulo Pimentel
dc.contributor.authorAndrade, Edilson Ferreira
dc.contributor.authorRezende, Alexandre Pingarilho
dc.contributor.authorImbeloni, Aline Amaral
dc.contributor.authorMuniz, Jose Augusto Pereira Carneiro
dc.contributor.authorPinto, Giovanny Reboucas
dc.contributor.authorSmith, Marilia de Arruda Cardoso [UNIFESP]
dc.contributor.authorBurbano, Rommel Rodríguez [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFed Univ Para
dc.contributor.institutionMinist Saude
dc.contributor.institutionUniv Fed Piaui
dc.date.accessioned2016-01-24T14:28:03Z
dc.date.available2016-01-24T14:28:03Z
dc.date.issued2012-12-01
dc.description.abstractBackground: Canova activates macrophages and indirectly induces lymphocyte proliferation. Here we evaluated the effects of Canova in cyclophosphamide-treated non-human primates.Methods: Twelve Cebus apella were evaluated. Four animals were treated with Canova only. Eight animals were treated with two doses of cyclophosphamide (50 mg/kg) and four of these animals received Canova. Body weight, biochemistry and hematologic analyses were performed for 40 days. Micronucleus and comet assays were performed for the evaluation of DNA damage.Results: We observed that cyclophosphamide induced abnormal WBC count in all animals. However, the group treated with cyclophosphamide plus Canova presented a higher leukocyte count than that which received only cyclophosphamide. Cyclophosphamide induced micronucleus and DNA damage in all animals. the frequency of these alterations was significantly lower in the Canova group than in the group without this medicine.Conclusions: Our results demonstrated that Canova treatment minimizes cyclophosphamide myelotoxicity in C. apella. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Genet, Dept Morfol & Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationFed Univ Para, Lab Citogenet Humana, Inst Ciencias Biol, BR-66059 Belem, Para, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Ginecol, Dept Tocoginecol, BR-04039032 São Paulo, Brazil
dc.description.affiliationFed Univ Para, Serv Cirurgia, Hosp Univ Joao de Barros Barreto, BR-66073000 Belem, Para, Brazil
dc.description.affiliationMinist Saude, Ctr Nacl Primatas, BR-77030000 Ananindeua, PA, Brazil
dc.description.affiliationUniv Fed Piaui, Lab Genet & Biol Mol, BR-64202020 Parnaiba, PI, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Genet, Dept Morfol & Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Ginecol, Dept Tocoginecol, BR-04039032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDCNPq: 550885/2007-2
dc.format.extent4412-4420
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2012.09.002
dc.identifier.citationFood and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 50, n. 12, p. 4412-4420, 2012.
dc.identifier.doi10.1016/j.fct.2012.09.002
dc.identifier.fileWOS000312288000023.pdf
dc.identifier.issn0278-6915
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35520
dc.identifier.wosWOS:000312288000023
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood and Chemical Toxicology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCanovaen
dc.subjectHomeopathic medicineen
dc.subjectCyclophosphamideen
dc.subjectNon-human primatesen
dc.subjectCebus apellaen
dc.titleThe protective effect of Canova homeopathic medicine in cyclophosphamide-treated non-human primatesen
dc.typeinfo:eu-repo/semantics/article
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