Plasma levels of acylated and total ghrelin in pediatric patients with chronic kidney disease

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dc.contributor.authorSoares Naufel, Maria Fernanda [UNIFESP]
dc.contributor.authorBordon, Milena [UNIFESP]
dc.contributor.authorAquino, Talita Marques de [UNIFESP]
dc.contributor.authorRibeiro, Eliane Beraldi [UNIFESP]
dc.contributor.authorAbreu Carvalhaes, Joao Tomas de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:43Z
dc.date.available2016-01-24T14:05:43Z
dc.date.issued2010-12-01
dc.description.abstractThis cross-sectional study set out to compare total and acyl ghrelin levels in children with mild chronic kidney disease (CKD) undergoing conservative treatment (n = 19) with children with end-stage renal disease (ESRD) undergoing hemodialysis (n = 24), and with healthy controls (n = 20). the relationship between ghrelin levels and parameters of renal function, nutritional status, and selective hormones were investigated. ESRD patients had higher total ghrelin levels than those with mild CKD or control individuals. However, acyl ghrelin did not differ between groups, indicating that the excess circulating ghrelin was desacylated. Since desacyl ghrelin has been shown to inhibit appetite, increased levels might contribute to protein-energy wasting in pediatric renal patients. When all 43 renal patients were combined, multiple regression analysis found age and glomerular filtration rate (GFR) to be significant negative predictors of total ghrelin. Acyl ghrelin was influenced negatively by age and positively by energy intake. Acyl to total ghrelin ratio related positively to GFR and energy intake. the results indicate that total but not acyl ghrelin is influenced by low GFR in children with CKD and suggests that ghrelin activation may be impaired in these patients. Since energy intake is a positive predictor of acyl ghrelin, the physiological control of ghrelin secretion appears to be altered in pediatric renal patients.en
dc.description.affiliationUniversidade Federal de São Paulo, Postgrad Program Pediat, BR-01417010 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-01417010 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pediat, BR-01417010 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Postgrad Program Pediat, BR-01417010 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-01417010 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pediat, BR-01417010 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent2477-2482
dc.identifierhttp://dx.doi.org/10.1007/s00467-010-1628-5
dc.identifier.citationPediatric Nephrology. New York: Springer, v. 25, n. 12, p. 2477-2482, 2010.
dc.identifier.doi10.1007/s00467-010-1628-5
dc.identifier.issn0931-041X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33113
dc.identifier.wosWOS:000283366600011
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofPediatric Nephrology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectChildrenen
dc.subjectChronic kidney diseaseen
dc.subjectGhrelinen
dc.subjectInsulin-like growth factor Ien
dc.subjectLeptinen
dc.subjectProtein-energy wastingen
dc.titlePlasma levels of acylated and total ghrelin in pediatric patients with chronic kidney diseaseen
dc.typeinfo:eu-repo/semantics/article
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