APOA4 Polymorphism as a Risk Factor for Unfavorable Lipid Serum Profile and Depression: A Cross-Sectional Study

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dc.contributor.authorOta, Vanessa Kiyomi [UNIFESP]
dc.contributor.authorChen, Elizabeth Suchi [UNIFESP]
dc.contributor.authorEjchel, Tatiana Flank [UNIFESP]
dc.contributor.authorFuruya, Tatiane Katsue [UNIFESP]
dc.contributor.authorMazzotti, Diego Robles [UNIFESP]
dc.contributor.authorCendoroglo, Maysa Seabra [UNIFESP]
dc.contributor.authorRamos, Luiz Roberto [UNIFESP]
dc.contributor.authorAraujo, Lara Quirino [UNIFESP]
dc.contributor.authorBurbano, Rommel Rodriguez [UNIFESP]
dc.contributor.authorCardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T18:07:20Z
dc.date.available2018-06-15T18:07:20Z
dc.date.issued2011-08-01
dc.description.abstractIntroduction: APOA1/C3/A4/A5 gene cluster is closely involved in lipid metabolism, and its polymorphisms have been associated with coronary heart disease and lipid plasma levels. Here, we aimed to investigate associations of APOC3 (3238C9G, j482C9T, 1100C9T) and APOA4 (Gln360His, Thr347Ser) polymorphisms in 382 individuals from a cohort of a Longitudinal Brazilian Elderly Study with major agerelated morbidities and with lipid and protein serum levels.Materials and Methods: The whole sample was genotyped by polymerase chain reactionYrestriction fragment length polymorphism. Descriptive statistics, logistic regression analysis, Student t test, deviation from Hardy-Weinberg, Bonferroni correction for multiple testing, and haplotype analyses were performed.Results: Although APOC3 1100T allele carriers presented lower triglyceride and very low density lipoprotein levels than non-T carriers, these associations disappeared after Bonferroni correction (P > 0.05). Moreover, APOA4 360His allele was associated with depression (P = 0.03), increased triglyceride (P = 0.035) and very low density lipoprotein (P = 0.035) levels, and reduced HDL levels (P = 0.0005). Haplotype analyses found an association between His/C/C haplotype (Gln360His/-482C>T/1100C>T) with depression, but this result was due to Gln360His polymorphism.Conclusions: Our data suggest that 360His allele might be a risk factor for depression and unfavorable lipid profile and depression for elderly people in the Brazilian population.en
dc.description.affiliationUniv Fed Sao Paulo, Disciplina Genet, Dept Morfol & Genet, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Disciplina Geriatria, Dept Med, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Disciplina Genet, Dept Morfol & Genet, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Disciplina Geriatria, Dept Med, BR-04023900 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenadoria de Aperfeicoamento de Pessoal de Ensino Superior (Brazil)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent966-970
dc.identifierhttp://dx.doi.org/10.2310/JIM.0b013e31822467cd
dc.identifier.citationJournal Of Investigative Medicine. Philadelphia: Lippincott Williams & Wilkins, v. 59, n. 6, p. 966-970, 2011.
dc.identifier.doi10.2310/JIM.0b013e31822467cd
dc.identifier.issn1081-5589
dc.identifier.urihttp://repositorio.unifesp.br/11600/44469
dc.identifier.wosWOS:000293062800030
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal Of Investigative Medicine
dc.rightsAcesso restrito
dc.subjectAPOC-IIIen
dc.subjectAPOA-IVen
dc.subjectelderly populationen
dc.subjectHDLen
dc.subjecttriglyceridesen
dc.titleAPOA4 Polymorphism as a Risk Factor for Unfavorable Lipid Serum Profile and Depression: A Cross-Sectional Studyen
dc.typeArtigo
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