Toll-like receptors-related genes in kidney transplant patients with chronic allograft nephropathy and acute rejection

Página do item simplificado
dc.contributor.authorNogueira, Eliana
dc.contributor.authorPonciano, Viviane Campos
dc.contributor.authorNaka, Erika L.
dc.contributor.authorMarques, Georgia D. M.
dc.contributor.authorCenedeze, Marcos A.
dc.contributor.authorSaraiva Camara, Niels Olsen
dc.contributor.authorPacheco-Silva, Alvaro [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:52:36Z
dc.date.available2016-01-24T13:52:36Z
dc.date.issued2009-06-01
dc.description.abstractIntroduction: Toll-like receptors (TLR) comprehend an emerging family of receptors that recognize pathogen-associated molecular patterns and promote the activation of leukocytes. Surgical trauma and ischemia-reperfusion injury are likely to provide exposure to endogenous ligands for TLR in virtually all kidney transplant recipients.Methods: Macroarray (GEArray OHS-018.2 Series-Superarray) analyses of 128 genes involved in TLR signaling pathway were performed in nephrectomy samples of patients with chronic allograft nephropathy (CAN) and acute rejection (AR, vascular and non vascular). the analysis of each membrane was performed by GEArray Expression Analysis Suite 2.0.Results: Macroarray profile identified a gene expression signature that could discriminate CAN and AR. Three genes were significantly expressed between CAN and vascular AR: Pellino 2; IL 8 and UBE2V1. in relation to vascular and non-vascular AR, there were only two genes with statistical significance: IL-6 and IRAK-3.Conclusion: Vascular and non-vascular AR and CAN showed different expression of a few genes in TLR pathway. the analysis of nephrectomy showed that activation of TLR pathway is present in AR and CAN. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Nefrol, Div Nephrol, Clin & Expt Immunol Lab, BR-4039032 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Immunol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Nefrol, Div Nephrol, Clin & Expt Immunol Lab, BR-4039032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent673-676
dc.identifierhttp://dx.doi.org/10.1016/j.intimp.2008.11.018
dc.identifier.citationInternational Immunopharmacology. Amsterdam: Elsevier B.V., v. 9, n. 6, p. 673-676, 2009.
dc.identifier.doi10.1016/j.intimp.2008.11.018
dc.identifier.issn1567-5769
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31566
dc.identifier.wosWOS:000266568800006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Immunopharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectMacroarrayen
dc.subjectChronic allograft nephropathyen
dc.subjectAcute vascular rejectionen
dc.subjectAcute non-vascular rejectionen
dc.subjectKidney transplanten
dc.subjectNephrectomyen
dc.titleToll-like receptors-related genes in kidney transplant patients with chronic allograft nephropathy and acute rejectionen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos