Pinealectomy-associated decrease in ribosomal gene activity in rats

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dc.contributor.authorPayão, Spencer Luiz Marques [UNIFESP]
dc.contributor.authorCarvalho, Cristina Valletta de [UNIFESP]
dc.contributor.authorSilva, Edson Roberto da
dc.contributor.authorLopes, Cristiane
dc.contributor.authorMarkus, Regina Pekelmann
dc.contributor.authorFloeter-Winter, Lucile Maria
dc.contributor.authorSmith, Marilia de Arruda Cardoso [UNIFESP]
dc.contributor.institutionFac Med Marilia
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T12:31:15Z
dc.date.available2016-01-24T12:31:15Z
dc.date.issued2001-01-01
dc.description.abstractA decrease in ribosomal gene activity is an essential feature of the aging process as it was observed in Alzheimer's disease, in elderly Down's patients and in elderly healthy people. It is well known that aging is also associated with a reduction in melatonin synthesis. We studied 24 male Wistar rats cytogenetically, by using Ag-stained NOR (6 three-month-old rats underwent. pinealectomy and were studied after 20 days; 6 control rats of the same age 6 three-month-old rats underwent pinealectomy and were studied after 8 months; 6 control rats of the same age). Our results indicate that the absence of the pineal gland leads to a decrease in NOR activity. Further studies are necessary to determine if pinealectomy in rats could provide an animal model for aging.en
dc.description.affiliationFac Med Marilia, Disciplina Genet & Biol Mol, Hemocentro, São Paulo, Brazil
dc.description.affiliationUnifesp, Escola Paulista Med, Dept Morfol, Disciplina Genet, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Parasitol, Inst Ciencias Biomed, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Fisiol Anim, Inst Biociencias, São Paulo, Brazil
dc.description.affiliationUnifespUnifesp, Escola Paulista Med, Dept Morfol, Disciplina Genet, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent105-108
dc.identifierhttps://dx.doi.org/10.1023/A:1011541302289
dc.identifier.citationBiogerontology. Dordrecht: Kluwer Academic Publ, v. 2, n. 2, p. 105-108, 2001.
dc.identifier.doi10.1023/A:1011541302289
dc.identifier.issn1389-5729
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/26451
dc.identifier.wosWOS:000169613400003
dc.language.isoeng
dc.publisherKluwer Academic Publ
dc.relation.ispartofBiogerontology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectNcleolus organizer regions (NOR)en
dc.subjectPineal glanden
dc.subjectRibosomal genesen
dc.titlePinealectomy-associated decrease in ribosomal gene activity in ratsen
dc.typeinfo:eu-repo/semantics/article
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