Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: a comparison with ebselen

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dc.contributor.authorPetronilho, Fabricia
dc.contributor.authorMichels, Monique
dc.contributor.authorDanielski, Lucineia G.
dc.contributor.authorGoldim, Mariana Pereira
dc.contributor.authorFlorentino, Drielly
dc.contributor.authorVieira, Andriele
dc.contributor.authorMendonca, Mariana G.
dc.contributor.authorTournier, Moema
dc.contributor.authorPiacentini, Barbara
dc.contributor.authorDella Giustina, Amanda
dc.contributor.authorLeffa, Daniela D.
dc.contributor.authorPereira, Gregorio W. [UNIFESP]
dc.contributor.authorPereira, Volnei D.
dc.contributor.authorTeixeira Da Rocha, Joao Batista
dc.date.accessioned2019-01-21T10:29:48Z
dc.date.available2019-01-21T10:29:48Z
dc.date.issued2016
dc.description.abstractObjetive: The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)(2) and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats. Methods: The effects of (PhSe)(2) and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations. Results: Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)(2) improved this response. Moreover, the treatment with (PhSe)(2) decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. LB was able only to reverse damage in lipids and the low levels of SOD in this animal model. Conclusions: The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)(2) more effective than EB. (C) 2016 Elsevier GmbH. All rights reserved.en
dc.description.affiliationClinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil
dc.description.affiliationClinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil
dc.description.affiliationLaboratory of Molecular and Cellular Biology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil
dc.description.affiliationDepartment of Pathology, Federal University of São Paulo, Sao Paulo, SP, Brazil
dc.description.affiliationInstitute of Pathological Anatomy and Histopathology DI-PREVER, Tubarão, SC, Brazil
dc.description.affiliationDepartment of Biochemistry and Molecular Biology, Natural and Exact Sciences Centers, Federal University of Santa Maria, Santa Maria, RS, Brazil
dc.description.affiliationUnifespDepartment of Pathology, Federal University of São Paulo, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent755-760
dc.identifierhttps://doi.org/10.1016/j.prp.2016.04.012
dc.identifier.citationPathology Research And Practice. Jena, v. 212, n. 9, p. 755-760, 2016.
dc.identifier.doi10.1016/j.prp.2016.04.012
dc.identifier.issn0344-0338
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49400
dc.identifier.wosWOS:000383523500001
dc.language.isoeng
dc.publisherFunpec-Editora
dc.relation.ispartofPathology Research And Practice
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDiphenyl Diselenideen
dc.subjectDss Induced-Colitisen
dc.subjectEbselenen
dc.subjectOxidative Stressen
dc.subjectUlcerative ColitisDextran Sulfate Sodiumen
dc.subjectLipid-Peroxidationen
dc.subjectBowel-Diseaseen
dc.subjectAnimal-Modelsen
dc.subjectRatsen
dc.subjectMetabolismen
dc.subjectSeleniumen
dc.subjectInjuryen
dc.subjectDamageen
dc.titleDiphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: a comparison with ebselenen
dc.typeinfo:eu-repo/semantics/article
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