Improved renal function after kidney transplantation is associated with heme oxygenase-1 polymorphism

Página do item simplificado
dc.contributor.authorOzaki, K. S.
dc.contributor.authorMarques, G. M.
dc.contributor.authorNogueira, E.
dc.contributor.authorFeitoza, R. Q.
dc.contributor.authorCenedeze, M. A.
dc.contributor.authorFranco, M. F. [UNIFESP]
dc.contributor.authorMazzali, M.
dc.contributor.authorSoares, M. P.
dc.contributor.authorPacheco-Silva, A.
dc.contributor.authorCamara, N. O. S. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionGulbenkian Inst Sci
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:51:41Z
dc.date.available2016-01-24T13:51:41Z
dc.date.issued2008-09-01
dc.description.abstractHeme oxygenase-1 (HO-1) has a microsatellite polymorphism based on the number of guanosine-thymidine nucleotide repeats (GT) repeats that regulates expression levels and could have an impact on organ survival post-injury. We correlated HO-1 polymorphism with renal graft function. the HO-1 gene was sequenced (N = 181), and the allelic repeats were divided into subclasses: short repeats (S) (< 27 repeats) and long repeats (L) (>= 27 repeats). A total of 47.5% of the donors carried the S allele. the allograft function was statistically improved six months, two and three yr after transplantation in patients receiving kidneys from donors with an S allele. for the recipients carrying the S allele (50.3%), the allograft function was also better throughout the follow-up, but reached statistical significance only three yr after transplantation (p = 0.04). Considering only those patients who had chronic allograft nephropathy (CAN; 74 of 181), allograft function was also better in donors and in recipients carrying the S allele, two and three yr after transplantation (p = 0.03). Recipients of kidney transplantation from donors carrying the S allele presented better function even in the presence of CAN.en
dc.description.affiliationUniversidade Federal de São Paulo, Lab Imunol Clin & Expt, Disciplina Nefrol, Dept Med,EPM,Nephrol Div, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Pathol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Div Nephrol, Campinas, SP, Brazil
dc.description.affiliationGulbenkian Inst Sci, Oeiras, Portugal
dc.description.affiliationUniv São Paulo, Dept Immunol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Lab Imunol Clin & Expt, Disciplina Nefrol, Dept Med,EPM,Nephrol Div, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Pathol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent609-616
dc.identifierhttp://dx.doi.org/10.1111/j.1399-0012.2008.00832.x
dc.identifier.citationClinical Transplantation. Malden: Wiley-Blackwell, v. 22, n. 5, p. 609-616, 2008.
dc.identifier.doi10.1111/j.1399-0012.2008.00832.x
dc.identifier.issn0902-0063
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30896
dc.identifier.wosWOS:000259341800013
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofClinical Transplantation
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectgraft survivalen
dc.subjectheme oxygenase-1en
dc.subjectpolymorphismen
dc.subjectrenal graft functionen
dc.subjectrenal transplantationen
dc.titleImproved renal function after kidney transplantation is associated with heme oxygenase-1 polymorphismen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos