Interruption of a study of cervical ripening with isosorbide mononitrate due to adverse effects

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dc.contributor.authorHatanaka, Alan Roberto [UNIFESP]
dc.contributor.authorMoron, Antonio Fernandes [UNIFESP]
dc.contributor.authorAquino, Márcia Maria Auxiliadora de [UNIFESP]
dc.contributor.authorSouza, E. de [UNIFESP]
dc.contributor.authorBussamra, Luiz Claudio de Silva [UNIFESP]
dc.contributor.authorAraujo, E. [UNIFESP]
dc.contributor.authorMattar, R. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T16:52:39Z
dc.date.available2018-06-15T16:52:39Z
dc.date.issued2012-01-01
dc.description.abstractPurpose of investigation: The objective of this study was to evaluate cervix length and the presence of cervical gland area (CGA) in ultrasounds performed before and after the administration of vaginal isosorbide mononitrate (IMN) for cervical ripening. Methods: We performed an observational, descriptive, and longitudinal study of pregnant patients indicated for labor induction and with a Modified Bishop Score (MBS) lower than six. For cervical ripening, 40 mg of vaginal IMN was administered at 0, 16, and 24 hours after the initiation of cervix preparation. Results: After enrolling 11 patients, the study had to be discontinued due to adverse effects. Three patients requested that they be withdrawn. Headaches were reported by all patients. Nausea, dizziness, dyspnea, and vomiting were also reported. The average cervical lengths at 0, 16, 24 and 36 hours were 27.6, 27.7, 25.9, and 23.0 mm, respectively. CGA disappeared in one of seven patients. Conclusions: The use of IMN appears to increase the MBS, slightly reducing cervical length without altering the appearance of CGA. Considering the importance of maternal wellbeing during labor, the routine use of IMN cannot be recommended for cervical ripening in the third trimester due to the frequency and intensity of side-effects.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Obstet, BR-04039034 Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Obstet, BR-04039034 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent175-180
dc.identifierhttp://www.irog.net/download/?magazine=21
dc.identifier.citationClinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 39, n. 2, p. 175-180, 2012.
dc.identifier.issn0390-6663
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43293
dc.identifier.wosWOS:000304899500011
dc.language.isoeng
dc.publisherI R O G Canada, Inc
dc.relation.ispartofClinical And Experimental Obstetrics & Gynecology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCervical ripeningen
dc.subjectIsosorbideen
dc.subjectAdverse effectsen
dc.subjectCervical length measurementen
dc.subjectInduced laboren
dc.titleInterruption of a study of cervical ripening with isosorbide mononitrate due to adverse effectsen
dc.typeinfo:eu-repo/semantics/article
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