Effects of estrogen and estrogen-progestogen therapy on homocysteine levels and their correlation with carotid vascular resistance

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dc.contributor.authorMachado, Rogerio Bonassi [UNIFESP]
dc.contributor.authorBaracat, Edmund Chada [UNIFESP]
dc.contributor.authorFernandes, Cesar Eduardo [UNIFESP]
dc.contributor.authorLakryc, Eli Marcelo [UNIFESP]
dc.contributor.authorLima, Geraldo Rodrigues de [UNIFESP]
dc.contributor.institutionFac Med Jundiai
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionABC Med Sch
dc.date.accessioned2016-01-24T13:49:12Z
dc.date.available2016-01-24T13:49:12Z
dc.date.issued2007-11-01
dc.description.abstractObjective. To evaluate the correlation between homocysteine levels and carotid vascular resistance in menopausal women submitted to estrogen and estrogen-progestogen therapy.Methods. Eighty-six women with a mean age of 52 years were enrolled in a prospective, randomized, double-blind, 6-month study. Patients were allocated to use one of three oral therapies: placebo (n = 26), micronized estradiol 2 mg/day (n = 30) or micronized estradiol 2 mg/day plus norethisterone acetate 1 mg/day (n = 30). Evaluation of homocysteine levels and Doppler sonography of the common carotid artery, used to calculate pulsatility index (PI), were carried out prior to initiating therapy and at the end of the study. the correlation between these two parameters was evaluated using Pearson's coefficient of correlation.Results. There was a significant reduction in homocysteine levels in the groups treated with estrogen alone or estrogen combined with norethisterone. PI was significantly lower only in users of estrogen alone; however, no significant correlation was found between homocysteine measurements and PI.Conclusion. No significant correlation was found between homocysteine levels and carotid vascular resistance following hormone therapy.en
dc.description.affiliationFac Med Jundiai, Jundiai Med Sch, Dept Gynecol & Obstet, BR-13202550 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationABC Med Sch, Dept Gynecol & Obstet, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent619-624
dc.identifierhttp://dx.doi.org/10.1080/09513590701581663
dc.identifier.citationGynecological Endocrinology. Abingdon: Informa Healthcare-taylor & Francis, v. 23, n. 11, p. 619-624, 2007.
dc.identifier.doi10.1080/09513590701581663
dc.identifier.issn0951-3590
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30138
dc.identifier.wosWOS:000251732500002
dc.language.isoeng
dc.publisherInforma Healthcare-taylor & Francis
dc.relation.ispartofGynecological Endocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.subjecthomocysteineen
dc.subjecthormone therapyen
dc.subjectestrogensen
dc.subjectvascular resistanceen
dc.subjectmenopauseen
dc.titleEffects of estrogen and estrogen-progestogen therapy on homocysteine levels and their correlation with carotid vascular resistanceen
dc.typeinfo:eu-repo/semantics/article
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