Evaluation of antimicrobial and antimalarial activities of crude extract, fractions and 4-nerolidylcathecol from the aerial parts of Piper umbellata L. (Piperaceae)

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dc.contributor.authorBagatela, Bianca Souza [UNIFESP]
dc.contributor.authorLopes, Andrey Pereira [UNIFESP]
dc.contributor.authorAffonso Fonseca, Fernando Luiz [UNIFESP]
dc.contributor.authorAndreo, Marcio Adriano [UNIFESP]
dc.contributor.authorNanayakkara, Dhammika N. P.
dc.contributor.authorBastos, Jairo Kenupp
dc.contributor.authorPerazzo, Fabio Ferreira [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Mississippi
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:34:49Z
dc.date.available2016-01-24T14:34:49Z
dc.date.issued2013-12-01
dc.description.abstractPresently, natural products, such as Piper umbellata L. (Piperaceae), have been evaluated as sources of antimicrobial agents with efficacies against microorganisms. the in vitro antimicrobial activity was performed by broth micro-dilution susceptibility assay, according to the protocols of the National Committee for Clinical Laboratory Standards, and described the antibacterial and antifungal activities of crude ethanolic extract and fractions obtained by partitions sequentially among water-methanol, methylene chloride and ethyl acetate, as well as the major constituent, 4-nerolidylcatechol from the aerial parts of P. umbellata L. Amphotericin B and ciprofloxacin were used as controls. Among the microorganism cultures, hydromethanol fraction demonstrated the pre-eminent antifungal activity. 4-Nerolidylcathecol was the only tested plant component that exhibited activity against all the selected microorganisms, suggesting its great potential as a source for the development of new drugs. in order to estimate the antimalarial activity of P. umbellata L., a micro-dilution method protocol, parasite lactate dehydrogenase assay, with a Plasmodium falciparum Sierra Leone (D6) clone was utilised. the antimalarial agent artemisinin was used as control. 4-Nerolidylcathecol exhibited the best antimalarial activity; however, it was not significant when compared with control. These in vitro results do not justify the use of P. umbellata L. in malaria patients. However, there is a possibility of 4-nerolidylcathecol, after biotransformation, exhibiting a significant antimalarial activity in in vivo assays. However, 4-nerolidylcathecol demonstrated to possess a broad antimicrobial activity which is, in fact, a promising source for the development of new therapeutic agents.en
dc.description.affiliationUniversidade Federal de São Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Exact & Earth Sci, BR-09913030 São Paulo, Brazil
dc.description.affiliationUniv Mississippi, Natl Ctr Nat Prod Res, Res Inst Pharmaceut Sci, Oxford, MS USA
dc.description.affiliationUniv São Paulo, Dept Pharmaceut Sci, Coll Pharmaceut Sci Ribeirao Preto, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Exact & Earth Sci, BR-09913030 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDCAPES: CBE/PDEE 00012/2003
dc.description.sponsorshipIDCAPES: BEX 2824/03-5
dc.format.extent2202-2209
dc.identifierhttp://dx.doi.org/10.1080/14786419.2013.821123
dc.identifier.citationNatural Product Research. Abingdon: Taylor & Francis Ltd, v. 27, n. 23, p. 2202-2209, 2013.
dc.identifier.doi10.1080/14786419.2013.821123
dc.identifier.issn1478-6419
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37054
dc.identifier.wosWOS:000327469000008
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.rightsAcesso restrito
dc.rights.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.subjectPiperaceaeen
dc.subjectPiper umbellata Len
dc.subjectantimicrobial activityen
dc.subjectantimalarial activityen
dc.subjectin vitroen
dc.subject4-nerolidylcathecolen
dc.titleEvaluation of antimicrobial and antimalarial activities of crude extract, fractions and 4-nerolidylcathecol from the aerial parts of Piper umbellata L. (Piperaceae)en
dc.typeArtigo
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