A new strategy for direct measurement of sinus atrial conduction time by sinus node threshold determination in a rat-isolated atrium

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dc.contributor.authorMagalhaes Galvao, Kleber de
dc.contributor.authorGodoy, Carlos Marcelo Gurjao de [UNIFESP]
dc.contributor.institutionUniv Mogi Cruzes
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:46Z
dc.date.available2016-01-24T12:41:46Z
dc.date.issued2007-01-01
dc.description.abstractIn this work we have searched for experimental evidence that would corroborate the idea that nodal threshold (NT) is the minimum electric field strength able to promote direct sinus node reset that, in turn, can be verified by a decrease in corrected sinus node recovery time (CSNRT). We have performed direct measurements of sinus node conduction time (SACT) and estimation of atrium sinus conduction time (ASCT). Stimulating pulses (pulse and train methods) generated a uniform electric field, with strength ranging from 1.5-fold to 5-fold the atrial threshold (AT), in the center of the perfusion chamber where isolated right atria were placed. the AT and NT were 67.4 and 192.7 mV cm(-1), respectively. the CSNRT values, obtained with stimulation strength below or above NT, were, respectively (ms; mean +/- standard error of mean) 38.1 +/- 0.42 and 25.2 +/- 0.30. in addition, we verified that NT corresponds to approximately 3-fold the AT; SACT was 1.34-fold ASCT and the overdrive suppression decreases with the increment of stimulation pulse strength. Therefore, by using a new and accurate approach for SNRT determination, we have provided additional experimental evidence for the development of alternative sinus node evaluation methods.en
dc.description.affiliationUniv Mogi Cruzes, Lab Electrofisiol Cardiaca Nucl Pesquisas Tecnol, Mogi Das Cruzes, SP, Brazil
dc.description.affiliationUnifespDepartamento de Farmacologia, Universidade Federal de São Paulo-Escola Paulista de Medicina, 04044-020, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent105-115
dc.identifierhttp://dx.doi.org/10.1088/0967-3334/28/1/010
dc.identifier.citationPhysiological Measurement. Bristol: Iop Publishing Ltd, v. 28, n. 1, p. 105-115, 2007.
dc.identifier.doi10.1088/0967-3334/28/1/010
dc.identifier.issn0967-3334
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29413
dc.identifier.wosWOS:000243750700010
dc.language.isoeng
dc.publisherIop Publishing Ltd
dc.relation.ispartofPhysiological Measurement
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://iopscience.iop.org/page/copyright
dc.subjectnodal thresholden
dc.subjectsinus atrial conduction timeen
dc.subjectelectric field stimulationen
dc.subjectisolated atriumen
dc.titleA new strategy for direct measurement of sinus atrial conduction time by sinus node threshold determination in a rat-isolated atriumen
dc.typeinfo:eu-repo/semantics/article
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