Therapeutic Assessment of Vulvar Squamous Intraepithelial Lesions with CO2 Laser Vaporization in Immunosuppressed Patients

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dc.citation.issue1
dc.citation.volume40
dc.contributor.authorLascasas Ribalta, Julisa Chamorro [UNIFESP]
dc.contributor.authorMateussi, Mariana Vendramin [UNIFESP]
dc.contributor.authorde Gois Speck, Neila Maria [UNIFESP]
dc.coverageRio De Janeiro Rj
dc.date.accessioned2020-07-02T18:52:10Z
dc.date.available2020-07-02T18:52:10Z
dc.date.issued2018
dc.description.abstractObjective A vulvar squamous intraepithelial lesion is deemed to be a preceding lesion to vulvar cancer, especially in women aged under 40 years, holders of an acquired or idiopathic immunosuppression. Several treatments have been used to treat these lesions. One of the aesthetically acceptable therapeutic methods is the CO2 laser vaporization. Methods In a transversal study, 46 records of immunosuppressed women bearing a vulvar low grade and/or high grade squamous intraepithelial lesion were selected out of the retrospective analysis, computing age, date of record, date of vulvar lesion treatment with CO2 laser, the time elapsed between the first and the last visit (in months), the number of visits, the presence or absence of condylomatous lesions in other female lower genital tract sites and whether or not recurrences and persistence of intraepithelial lesions have been noticed during the follow-up. Results Patients bearing vulvar high-grade squamous intraepithelial lesion and immunosuppressed (serumpositive for human immunodeficiency virus [HIV] or with solid organs transplantation) have shown a higher level of persistence of lesions and a higher chance of having other areas of the female lower genital tract involved. Conclusion While the CO2 laser vaporization is the most conservative method for the treatment of vulvar high-grade intraepithelial lesions, it is far from being the ideal method, due to the intrinsic infection features considered. The possibility of persistence, recurrences and spontaneous limited regression indicates that a closer surveillance in the long-term treated cases should be considered, in special for immunosuppressed patients.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Council for Scientific and Technological Development in Research - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.format.extent26-31
dc.identifierhttp://dx.doi.org/10.1055/s-0037-1618573
dc.identifier.citationRevista Brasileira De Ginecologia E Obstetricia. Rio De Janeiro Rj, v. 40, n. 1, p. 26-31, 2018.
dc.identifier.doi10.1055/s-0037-1618573
dc.identifier.fileWOS000422694200005.pdf
dc.identifier.issn0100-7203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53921
dc.identifier.wosWOS:000422694200005
dc.language.isoeng
dc.publisherFederacao Brasileira Soc Ginecologia & Obstetricia-Febrasgo
dc.relation.ispartofRevista Brasileira De Ginecologia E Obstetricia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectvulvar intraepithelial neoplasiaen
dc.subjectusual vulvar intraepithelial neoplasiaen
dc.subjectvulvar high-grade squamous intraepithelial lesionen
dc.subjectCO2 laseren
dc.subjectlaser therapyen
dc.titleTherapeutic Assessment of Vulvar Squamous Intraepithelial Lesions with CO2 Laser Vaporization in Immunosuppressed Patientsen
dc.typeinfo:eu-repo/semantics/article
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