Pre-test metyrapone impairs memory recall in fear conditioning tasks: lack of interaction with I--adrenergic activity

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dc.contributor.authorCareaga, Mariella Bodemeier Loayza [UNIFESP]
dc.contributor.authorTiba, Paula Ayako
dc.contributor.authorOta, Simone Marie [UNIFESP]
dc.contributor.authorSuchecki, Deborah [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2016-01-24T14:40:13Z
dc.date.available2016-01-24T14:40:13Z
dc.date.issued2015-03-03
dc.description.abstractCognitive processes, such as learning and memory, are essential for our adaptation to environmental changes and consequently for survival. Numerous studies indicate that hormones secreted during stressful situations, such as glucocorticoids (GCs), adrenaline and noradrenaline, regulate memory functions, modulating aversive memory consolidation and retrieval, in an interactive and complementary way. Thus, the facilitatory effects of GCs on memory consolidation as well as their suppressive effects on retrieval are substantially explained by this interaction. On the other hand, low levels of GCs are also associated with negative effects on memory consolidation and retrieval and the mechanisms involved are not well understood. the present study sought to investigate the consequences of blocking the rise of GCs on fear memory retrieval in multiple tests, assessing the participation of (3-adrenergic signaling on this effect. Metyrapone (GCs synthesis inhibitor; 75 mg/kg), administered 90 min before the first test of contextual or tone fear conditioning (TFC), negatively affected animals' performances, but this effect did not persist on a subsequent test, when the conditioned response was again expressed. This result suggested that the treatment impaired fear memory retrieval during the first evaluation. the administration immediately after the first test did not affect the animals' performances in contextual fear conditioning (CFC), suggesting that the drug did not interfere with processes triggered by memory reactivation. Moreover, metyrapone effects were independent of beta-adrenergic signaling, since concurrent administration with propranolol (2 mg/kg), alpha,beta-adrenergic antagonist, did not modify the effects induced by metyrapone alone. These results demonstrate that pre-test metyrapone administration led to negative effects on fear memory retrieval and this action was independent of a beta-adrenergic signaling.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Matemat Comp & Cognicao, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fund de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundacao de Amparo Pesquisa do Estado de São Paulo
dc.description.sponsorshipIDFundacao de Amparo Pesquisa do Estado de São Paulo: FAPESP 2011/16977-8
dc.format.extent11
dc.identifierhttp://dx.doi.org/10.3389/fnbeh.2015.00051
dc.identifier.citationFrontiers in Behavioral Neuroscience. Lausanne: Frontiers Research Foundation, v. 9, 11 p., 2015.
dc.identifier.doi10.3389/fnbeh.2015.00051
dc.identifier.fileWOS000352267900002.pdf
dc.identifier.issn1662-5153
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38876
dc.identifier.wosWOS:000352267900002
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofFrontiers in Behavioral Neuroscience
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmemoryen
dc.subjectmetyraponeen
dc.subjectpropranololen
dc.subjectfear conditioningen
dc.subjectretrievalen
dc.titlePre-test metyrapone impairs memory recall in fear conditioning tasks: lack of interaction with I--adrenergic activityen
dc.typeinfo:eu-repo/semantics/article
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