Factorial design study to access the "green" iodocyclization reaction of 2-allylphenols

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dc.citation.issue2
dc.citation.volume5
dc.contributor.authorCorrea, Michelle Fidelis [UNIFESP]
dc.contributor.authorBarbosa, Alefe Jhonatas Ramos [UNIFESP]
dc.contributor.authorSato, Rie [UNIFESP]
dc.contributor.authorJunqueira, Luis Otavio [UNIFESP]
dc.contributor.authorPoliti, Mario Jose
dc.contributor.authorRando, Daniela Goncales [UNIFESP]
dc.contributor.authorFernandes, Joao Paulo dos Santos [UNIFESP]
dc.coverageBerlin
dc.date.accessioned2020-07-22T13:23:14Z
dc.date.available2020-07-22T13:23:14Z
dc.date.issued2016
dc.description.abstractIodocyclization of 2-allylphenols is a suitable method to access furans and dihydrofurans with adequate yields. Several methodologies to iodocyclization are reported in the literatureen
dc.description.abstracthowever, since some data about the conditions are conflicting, a more systematic approach is needed to define the best conditions. In this work, we performed a full 22 factorial design to study the influence of solvent (water or EtOH: water (1: 9) mixture) and the addition of NaHCO3 in iodine-promoted cyclization of 2-allylphenols. The results have shown water as the best solvent to be employed in the cyclization of liquid 2-allylphenols, and the presence of NaHCO 3 leads to lower yields. Several examples of 2-iodomethyl-2,3-dihydrobenzofurans preparations are reported using the optimized conditionsen
dc.description.abstracthowever, high yields are only observed when liquid 2-allylphenols were used.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Exact & Earth Sci, R Sao Nicolau 210, BR-09913030 Diadema, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Biochem, Inst Chem, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Exact & Earth Sci, R Sao Nicolau 210, BR-09913030 Diadema, SP, Brazil
dc.description.provenanceMade available in DSpace on 2020-07-22T13:23:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo state (FAPESP)
dc.description.sponsorshipBrazil government (CNPq)
dc.description.sponsorshipCAPES
dc.description.sponsorshipIDFAPESP: 2013/01875-0
dc.description.sponsorshipIDFAPESP: 2013/20479-9
dc.description.sponsorshipIDCNPq: 455411/2014-0
dc.format.extent145-151
dc.identifierhttp://dx.doi.org/10.1515/gps-2015-0101
dc.identifier.citationGreen Processing And Synthesis. Berlin, v. 5, n. 2, p. 145-151, 2016.
dc.identifier.doi10.1515/gps-2015-0101
dc.identifier.fileWOS000374997600006.pdf
dc.identifier.issn2191-9542
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56112
dc.identifier.wosWOS:000374997600006
dc.language.isoeng
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofGreen Processing And Synthesis
dc.rightsAcesso restrito
dc.subjectdihydrobenzofuran synthesisen
dc.subjectfactorial designen
dc.subjectgreen chemistryen
dc.subjectiodocyclizationen
dc.titleFactorial design study to access the "green" iodocyclization reaction of 2-allylphenolsen
dc.typeArtigo
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