Low frequency fluctuation of brain spontaneous activity and obsessive compulsive symptoms in a large school-age sample

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dc.citation.volume96
dc.contributor.authorHoexter, Marcelo Q.
dc.contributor.authorBiazoli, Claudinei E., Jr.
dc.contributor.authorAlvarenga, Pedro G.
dc.contributor.authorBatistuzzo, Marcelo C.
dc.contributor.authorSalum, Giovanni A.
dc.contributor.authorGadelha, Ary
dc.contributor.authorPan, Pedro M.
dc.contributor.authorAnes, Mauricio
dc.contributor.authorMancini-Martins, Leticia
dc.contributor.authorMoura, Luciana M.
dc.contributor.authorSoriano-Mas, Caries
dc.contributor.authorAquilla, Marco A. G. Del'
dc.contributor.authorArnaro, Edson, Jr.
dc.contributor.authorRohde, Luis A.
dc.contributor.authorJackowski, Andrea P.
dc.contributor.authorBressan, Rodrigo A.
dc.contributor.authorMiguel, Euripedes C.
dc.contributor.authordo Rosario, Maria C.
dc.contributor.authorSato, Joao R.
dc.coverageOxford
dc.date.accessioned2020-07-02T18:52:12Z
dc.date.available2020-07-02T18:52:12Z
dc.date.issued2018
dc.description.abstractBackground: The present study was designed to explore alterations in brain dynamics at rest that are associated with Obsessive Compulsive Symptoms (OCS) in childhood by measuring low frequency fluctuation of spontaneous brain activity in a large school community sample from a developing country. Method: Resting state functional magnetic resonance imaging data were collected in a sample of 655 children and adolescents (6-15 years old) from the brazilian 'High Risk Cohort Study for Psychiatric Disorders (HRC)'. OCS were assessed using items from the Compulsion and Obsessions section of the Development and Well-Being Assessment (DAWBA). The correlation between the fractional amplitude of low frequency fluctuations (fALFF) and the number of OCS were explored by using a general linear model, considering fALFF as response variable, OCS score as regressor and age, gender and site as nuisance variables. Results: The number of OCS was positively correlated with the fALFF coefficients at the right sensorimotor cortex (pre-motor, primary motor cortex and post-central gyrus) and negatively correlated with the fALFF coefficients at the insula/superior temporal gyrus of both hemispheres. Our results were specific to OCS and not due to associations with overall psychopathology. Conclusions: Our results suggest that brain spontaneous activity at rest in the sensorimotor and insular/superior-temporal cortices may be involved in OCS in children. These findings need independent replication and future studies should determine whether brain spontaneous activity changes within these regions might be predictors of risk for obsessive-compulsive disorder latter in life.en
dc.description.affiliationUniv Sao Paulo, Dept & Inst Psiquiatria, Fac Med FMUSP, Sao Paulo, SP, Brazil
dc.description.affiliationCNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Math Comp & Cognit, Santo Andre, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliationHosp Clin Porto Alegre, Med Phys & Radioprotect Serv, Porto Alegre, RS, Brazil
dc.description.affiliationCarlos III Hlth Inst, Dept Psychiat, Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Barcelona, Spain
dc.description.affiliationCarlos III Hlth Inst, CIBERSAM, Barcelona, Spain
dc.description.affiliationUniv Autonoma Barcelona, Dept Psychobiol & Methodol Hlth Sci, Barcelona, Spain
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Radiol, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Psychiat, Child & Adolescent Psychiat Unit UPIA, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Psychiat, Child & Adolescent Psychiat Unit UPIA, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation - FAPESP
dc.description.sponsorshipCNPq
dc.description.sponsorshipFAPESP
dc.description.sponsorshipIDFAPESP: 2012/50722-0
dc.description.sponsorshipIDFAPESP: 2013/00506-1
dc.description.sponsorshipIDFAPESP: 2008/57896-8
dc.description.sponsorshipIDFAPESP: 2016/05865-8
dc.description.sponsorshipIDFAPESP: 2013/08531-5
dc.description.sponsorshipIDFAPESP: 2016/02246-5
dc.description.sponsorshipIDFAPESP: 2013/10498-6
dc.description.sponsorshipIDCNPq: 442026/2014-5
dc.description.sponsorshipIDCNPq: 573974/2008-0
dc.format.extent224-230
dc.identifierhttp://dx.doi.org/10.1016/j.jpsychires.2017.10.009
dc.identifier.citationJournal Of Psychiatric Research. Oxford, v. 96, p. 224-230, 2018.
dc.identifier.doi10.1016/j.jpsychires.2017.10.009
dc.identifier.fileWOS000419412800030.pdf
dc.identifier.issn0022-3956
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53946
dc.identifier.wosWOS:000419412800030
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofJournal Of Psychiatric Research
dc.rightsAcesso restrito
dc.subjectAmplitude of low-frequency fluctuationen
dc.subjectDevelopmenten
dc.subjectObsessive compulsive disorderen
dc.subjectObsessive-compulsive symptomsen
dc.subjectResting-state functional magnetic resonance imagingen
dc.subjectSpontaneous neuronal activityen
dc.titleLow frequency fluctuation of brain spontaneous activity and obsessive compulsive symptoms in a large school-age sampleen
dc.typeArtigo
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