Lorazepam induces an atypical dissociation of visual and auditory event-related potentials

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dc.contributor.authorPompeia, S.
dc.contributor.authorManzano, G. M.
dc.contributor.authorGalduroz, JCF
dc.contributor.authorTufik, S.
dc.contributor.authorBueno, OFA
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:45Z
dc.date.available2016-01-24T12:33:45Z
dc.date.issued2003-03-01
dc.description.abstractLorazepam has been reported to atypically disrupt visual processing compared to other benzodiazepines (BZs), but it is not known to what extent this effect extends to impairment in other modalities. Our objective was to compare the effects of lorazepam with those of flunitrazepam, a BZ with standard effects, on visual and auditory event-related potentials (ERPs) using the same paradigm. the study followed a placebo-controlled, double-blind, parallel group-design and involved single oral doses of lorazepam (2.0 mg), flunitrazepam (1.2 mg) and placebo. Thirty-six young, healthy subjects completed a test battery before and after treatment including classic behavioural tests, visual and auditory ERPs. Both drugs led to comparable alterations on behavioural tests and double-dissociations were found, indicating that the doses used were equipotent: lorazepam was more deleterious than flunitrazepam and placebo in fragmented shape identification, while simple reaction times were prolonged for flunitrazepam in comparison to lorazepam and placebo. Effects on P3 latencies were also distinct: alterations in both modalities for flunitrazepam were equivalent and greater than placebo's. in contrast, lorazepam at the frontal and central electrode sites led to greater changes in visual than in auditory latency, and also to longer visual latencies than flunitrazepam and placebo, but lorazepam's auditory latency effects were only different to placebo's at the parietal electrode site. Peripheral visual changes were not responsible for these effects. Differences in the impairment profile between equipotent doses of lorazepam and flunitrazepam suggests that lorazepam induces atypical central visual processing changes.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol, Setor Neurofisiol Clin, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol, Setor Neurofisiol Clin, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent31-40
dc.identifierhttp://dx.doi.org/10.1177/0269881103017001690
dc.identifier.citationJournal of Psychopharmacology. London: Sage Publications Ltd, v. 17, n. 1, p. 31-40, 2003.
dc.identifier.doi10.1177/0269881103017001690
dc.identifier.issn0269-8811
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27173
dc.identifier.wosWOS:000181755500005
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofJournal of Psychopharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjectbenzodiazepinesen
dc.subjectevent-related potentialsen
dc.subjectERPen
dc.subjectflunitrazepamen
dc.subjectlorazepamen
dc.subjectP3en
dc.subjectP100en
dc.subjectvisionen
dc.titleLorazepam induces an atypical dissociation of visual and auditory event-related potentialsen
dc.typeinfo:eu-repo/semantics/article
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